• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2002 Fiscal Year Final Research Report Summary

Involvement of immune system to the inferior alveolar nerve injury.

Research Project

Project/Area Number 13672134
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHyogo College of Medicine

Principal Investigator

TOKUNAGA Atsushi  Hyogo College of Medicine, Assistant Professor, 医学部, 講師 (70254521)

Co-Investigator(Kenkyū-buntansha) KONDO Eiji  Matsumoto Dental University, Professor, 歯学部, 教授 (50273636)
NOGUCHI Koichi  Hyogo College of Medicine, Professor, 医学部, 教授 (10212127)
Project Period (FY) 2001 – 2002
Keywordsneuritis / peripheral nerve / cytokine / glia / dorsal root ganglion / nerve injury / rat / immunohistochemistry
Research Abstract

Eliav et al. (Pain 83 162-182, 1999) reported that peripheral neuritis of the rat sciatic nerve induced hyperalgesia and allodynia.
We modified the Eliav's model in order to prevent physical stimulation to the sciatic nerve. Oxycel was directly placed on the sciatic nerve without any touch of instruments, and saturated with Complete Freund's Adjuvant (CFA). ED-1 (a marker for macrophages), TNFalpha and IL-1beta immunoreactivity were detected from post-operative day 1 by immunohistochemistry. TNFalpha and IL-1beta immunoreactive cells were thought to be Schwann cells. Myelin basic protein was abolished on the sciatic nerve. This suggests that demuelination was occurred in the sciatic nerve. Furthermore, dorsal root ganglion neurons expressed Neuropeptide Y, GAP-43 and ATF3, which were well known to be expressed on axotomized DRG neurons.
Those findings suggested that activating of peripheral immune system might induce peripheral nerve injury.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Dai. Y.: "Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization"J. Neurosci.. 22. 7734-7745 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Obata. K.: "Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation"Pain. 99. 121-132 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukuoka. T.: "VR1, but not P2X3, increases in the spared L4 DRG in rats with L5 spinal nerve ligation"Pain. 99. 111-120 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tachibana. T.: "Analysis of Gene Expression Following Spinal Cord Injury in Rat using cDNA Microarray"Neurosci. Lett.. 327. 133-137 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kondo. E.: "Involvement of glutamate receptors on hyperexcitability of wide dynamic range neurons in the gracile nucleus of the rats with experimental mononeuropathy"Pain. 95. 153-163 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Liu. Y.: "Heme Oxygenase-1 Expression Following Spinal Cord Injury ; the Induction in Activated Neutrophils"J. Neurotrauma.. 19. 479-490 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Dai T., Iwata K., Fukuoka T., Kondo E., Tokunaga A., Yamanaka H., Tachibana T., Liu Y., and Noguchi K.: "Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization"J Neurosci. 22. 7737-7745 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Obata K., Yamanaka H., Fukuoka T., Dai Y., Tokunaga A., Hashimoto N., Yoshikawa H., and Noguchi K.: "Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats"Pain. 101. 65-77 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuoka T., Tokunaga A., Tachibana T., Dai Y., Yamanaka H., and Noguchi K.: "VR1, but not P2X3 increases in the spared L4 DRG in rats with L5 spinal nerve ligation"Pain. 99. 111-120 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tachibana T., Noguchi K., and Ruda MA.: "Analysis of Gene Expression Following Spinal Cord Injury in Rat using cDNA Microarray"Neurosci. Lett.. 327. 133-137 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo E., Iwata K., Ogawa A., Tashiro A., Tsubio Y., Fukuoka T., Yamanaka H., Dai Y., Morimoto T., and Noguchi K.: "Involvement of glutamate receptors on hyperexcitability of wide dynamic range neurons in the gracile nucleus of the rats with experimental mononeurophathy"Pain. 95. 153-163 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Liu Y., Tachibana T., Dai Y., Kondo E., Fukuoka T., Yamanaka H., and Noguchi K.: "Heme Oxygenase-1 Expression Following Spinal Cord Injury; the Induction in Activated Neutrophils"J. Neurotrauma. 19. 479-490 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2004-04-14  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi