Clinical evaluation and basic research for long term use of a newly developed miniature mixed-flow pump

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 14370414
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: OITA UNIVERSITY
• Principal Investigator: HADAMA Tetsuo Oita University, Faculty of Medicine, Professor, 医学部, 教授 (00145377)
• Co-Investigator(Kenkyū-buntansha): SAKO Hidenori Oita University, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (20315344) ; MIYAMOTO Shinji Oita University, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (70253797) ; ANAI Hirofumi Oita University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (20291544) ; HAMAMOTO Hirotsugu Oita University, Faculty of Medicine, Staff Doctor, 医学部, 医員 ; IWATA Eriko Oita University, Faculty of Medicine, Staff Doctor, 医学部, 医員
• Project Period (FY): 2002 – 2003
• Keywords: Cardiopulmonary bypass / Continuous flow / Mixed-flow pump

Research Abstract

We performed a clinical evaluation and a basic research for long term use of a newly developed miniature mixed-flow blood pump (MFP) for cardiopulmonary bypass (CPB). In the clinical evaluation, 10 patients received a CPB with the MFP. The pump flow was maintained steadily. The MFP was controlled very smoothly at starting and weaning state. Changes in plasma free hemoglobin, lactate dehydrogenase, platelet count, β-thromboglobulin and thrombin-antithrombin complex showed no significant differences from those of a control pump. We believe the MFP had good controllability and less damage on the blood. Left ventricular bypasses were established in 7 goats to evaluate durability and antithrombogenesity. In two goats, experiments were finished after 14 days bypass. Thrombus formations were obtained around a bearing. We believe some improvements of bearings for long term use.