2004 Fiscal Year Final Research Report Summary
Analysis of expression of new prognostic factor run23-HI gene in non-Hodgkin's lymphoma
| Project/Area Number |
14570995
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kitasato University |
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Principal Investigator |
NIITU Nozomi Kitasato Univ., School of Medicine, Assistant Professor, 医学部, 講師 (20256697)
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| Project Period (FY) |
2002 – 2004
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| Keywords | Non-Hodgkin's lymphoma / Serum nm23-H1 / ELISA / Cytoplasmic nm23-H1 / Immunohistochemistry |
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| Research Abstract |
Recently, we established an ELISA technique for measuring nm23-H1 protein in serum, and found that the serum nm23-H1 level is a potential prognostic factor for patients with non-Hodgkin's lymphoma. We used immunohistochemistry to examine the expression of nm23-H1 by the lymphoma cells in patients with diffuse large B-cell lymphoma (DLBCL) or peripheral T-cell lymphoma (PTCL). By analyzing a consecutive series of 172 untreated DLBCL patients, 100 (58.1%) were strongly positive. The cytoplasmic nm23 expression in lymphoma cells correlated significantly with the serum nm23-H1 level. There was a significant correlation between patients with cytoplasmic nm23-positive lymphoma and those with PS 2-4, stage III/IV, bulky mass, B symptoms, elevated serum level of sIL-2R, and elevated serum level of CRP. Overall and progression-free survival rates were significantly lower in patients with nm23-H1-positive lymphomas than in those with nm23-H1-negative lymphomas. Similar difference was seen betwee
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n patients with high and low serum levels of nm23-H1. Thus, the correlation between presence or absence of cytoplasmic nm23-H1 expression and serum nm23-H1 levels suggests that serum nm23-H1 is produced directly by lymphoma cells. Expression of nm23-H1, TIA-1 or granzyme B was examined by immunohistochemistry in 137 previously untreated patients with the lymphoma. The relationship between the results and clinical outcome was examined in 81 patients with angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, or peripheral T-cell lymphoma-unspecified. It was found that nm23-H1 was produced by the neoplastic cells of some of the lymphoma and the expression rates of nm-23-H1, TIA-1, and granzyme B were 36.5%, 78.8%, and 32.8%, respectively. nm23-H1-positive or TIA-1-positive group had significantly shorter overall and disease-free survivals. Furthermore, a multivariate analysis confirmed the nm23-H1 expression to be an independent prognostic factor.
Because of nm23-HI production by lymphoma cells, we expect to see the development of new treatments targeting nm23 overexpression. Furthermore, the nm23-H1 protein can be an important prognostic factor in the above types of lymphoma. Less
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Research Products
(12 results)
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[Journal Article] Clinical Significance of Intracytoplasmic nm23-H1 Expression in Diffuse Large B-Cell Lymphoma.2004
Author(s)
Niitsu, N., Nakamine, H., Okamoto, M., Akamatsu, H., Higashihara, M., Honma, Y., Okabe-Kado, J., Hirano, M.
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Journal Title
Clin Cancer Res. 10
Pages: 2482-2490
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Clinical significance of nm23-H1 proteins expressed on cell surface in non-Hodgkin's lymphoma.2003
Author(s)
Niitsu, N., Honma, Y., Iijima, K., Takagi, T., Higashihara, M., Sawada, U., Okabe-Kado, J.
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Journal Title
Leukemia 17
Pages: 196202
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Serum levels of the nm23-H1 protein and their clinical implication in extranodal NK/T cell lymphoma.2003
Author(s)
Niitsu, N., Okamoto, M., Honma, Y., Nakamine, H., Tamaru, J.I., Nakamura, S., Yoshino, T., Higashihara, M., Hirano, M., Okabe-Kado, J.
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Journal Title
Leukemia 17
Pages: 987-990
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma.2003
Author(s)
Niitsu, N., Nakamine, H., Okamoto, M., Akamatsu, H., Honma, Y., Higashihara, M., Okabe-Kado, J., Hirano, M.
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Journal Title
Br J Haematol 123
Pages: 621-630
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Simultaneous elevation of the serum concentrations of vascular endothelial growth factor and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma.2002
Author(s)
Niitsu, N., Okamoto, M., Nakamine, H., Yoshino, T., Tamaru, J-I., Nakamura, S., Higashihara, M., Hirano, M.
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Journal Title
Eur J Haematol 68
Pages: 91-100
Description
「研究成果報告書概要(欧文)」より
