2003 Fiscal Year Final Research Report Summary
Prevortion of neural cell death and decveare of home mineral density after spinal cord injury
| Project/Area Number |
14571383
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kagawa University Faculty of Medecine |
|---|
Principal Investigator |
MORI Satoshi Kagawa University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (00190992)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITANO Toshifumi Kagawa University, Faculty of Medicine, Professor, 医学部, 教授 (60145042)
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Keywords | spinal cord injury / regeneration / radial glia / systemic hypothermia / apoptosis / 放射状グリア / 3CB2抗原 / 軟膜下アストロサイト |
|---|
| Research Abstract |
We investigated that prevention of neural cell death and decrease of home mineral density after spinal cord injury (SCI). Systemic hypothermia shows a neuroprotective effect after SCI by attenuating post-traumatic apoptotic cell death.
And, we analyzed mechanism of neural regenerution and repuir after SCI. Our study demonstrated the re-emergence of radial glia after SCI in adult mamnals. Radial glia derived from subpial astrocyte may play an important role in neural repair and regeneration after SCI.
|
