2003 Fiscal Year Final Research Report Summary

Prevortion of neural cell death and decveare of home mineral density after spinal cord injury

Research Project

Project/Area Number	14571383
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Kagawa University Faculty of Medecine
Principal Investigator	MORI Satoshi Kagawa University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (00190992)
Co-Investigator(Kenkyū-buntansha)	ITANO Toshifumi Kagawa University, Faculty of Medicine, Professor, 医学部, 教授 (60145042)
Project Period (FY)	2002 – 2003
Keywords	spinal cord injury / regeneration / radial glia / systemic hypothermia / apoptosis / 放射状グリア / 3CB2抗原 / 軟膜下アストロサイト
Research Abstract	We investigated that prevention of neural cell death and decrease of home mineral density after spinal cord injury (SCI). Systemic hypothermia shows a neuroprotective effect after SCI by attenuating post-traumatic apoptotic cell death. And, we analyzed mechanism of neural regenerution and repuir after SCI. Our study demonstrated the re-emergence of radial glia after SCI in adult mamnals. Radial glia derived from subpial astrocyte may play an important role in neural repair and regeneration after SCI.

(4 results)