2003 Fiscal Year Final Research Report Summary
Identification of genes for premature ovarian failure
| Project/Area Number |
14571589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
ISHIZUKA Bunpei St.Marianna University School of Medicine, Department of Obstetrics and Gynecology, Professor, 医学部, 教授 (80097336)
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| Co-Investigator(Kenkyū-buntansha) |
MIMURO Takuhiko St.Marianna University School of Medicine, Department of Ob/Gyn, Instructor, 医学部, 助手 (30308457)
MIMURO Takahisa St.Marianna University School of Medicine, Department of Ob/Gyn, Assistant Professor, 医学部, 講師 (40209854)
ITOH Masanori, t. St.Marianna University School of Medicine, Department of Chemistry, Assistant Professor, 医学部, 講師 (30257349)
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| Project Period (FY) |
2002 – 2003
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| Keywords | premature ovarian failure / ovary / gene / XO mice |
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| Research Abstract |
Premature ovarian failure (POF) is defined as the cessation of menses for > 6 months before the age of 40 years, and affects about % of women (Coulam et al., 1986). It has been suggested that the fragile X mental retardation gene (FMR1) is associated with POF (Uzielli et al., 1999). Two groups have reported that POF occurs at an increased frequency in women carrying the fragile X premutaion (50-200 CGC trinucleotide repeated in the 5' prime untranslated region of the FMR1 gene) (Conway et al., 1998 ; Uzuelli et al., 1999). In this study, we also found that 3 of 62 Japanese patients with POF were carriers of the fragile X premutaion, suggesting the association of the fragile X premutaion and POF. In addition, FMR1 gene product seemed to express in the rat ovary, which suggests that FMR1 gene product may play a role in ovarian function. Furthermore, we are trying to identify other FMR1 gene mutations associating with POF and to determine all nucleotide sequence of FMR1 gene.
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Research Products
(13 results)
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[Publications] Kiguchi K, Ishikawa I, Tokieda Y, Iguchi M, Ishikawa C, Iwata M, Ishizuka B, Yoshikawa H, Tachibana T, Hashimoto H, Ishikawa H: "Establishment and characterization of a lymphoepithelial-like carcinoma cell line (HUUCLEC) derived from the human uterine cervix"Hum Cell. 15(2). 97-102 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yasuda M, Saito K, Kobayashi Y, Muramatsu T, Miyamoto T, Murakami M, Shiozuka T, Ishizuka B, Makino T, Kajiwara H, Osamura RY: "Serum carbohydrate antigen elevations in endometrial adenocarcinomas : Characterization of DU-PAN-2 expression as a tumor marker"J Obstet Gynaecol Res. 30(1). 59-64 (2004)
Description
「研究成果報告書概要(欧文)」より
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