2005 Fiscal Year Final Research Report Summary
Research on the effects of tamoxifen in rats with estrogen- and progesterone-receptor negative ovarian cancer.
| Project/Area Number |
14571595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SUGIYAMA Toru Iwate Medical University, School of Medicine, Professor, 医学部, 教授 (40162903)
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| Co-Investigator(Kenkyū-buntansha) |
IZUTSU Toshihiko Iwate Medical University, School of Medicine, Professor, 医学部, 教授 (00103739)
YOSHIZAKI Akira Iwate Medical University, School of Medicine, Lecturer, 医学部, 助手 (40200969)
SHOJI Tadahiro Iwate Medical University, School of Medicine, Research Associate, 医学部, 助手 (00337148)
OTA Shunichiro Kurume University, School of Medicine, Research Associate, 医学部, 助手 (40289476)
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| Project Period (FY) |
2002 – 2005
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| Keywords | Tamoxifen / apoptosis / cell cycle / ovarian cancer / anti-tumor effect |
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| Research Abstract |
The effects of tamoxifen (TAM) on the growth and cell cycle kinetics in an estrogen- and progesterone-receptor negative ovarian cancer in rats were evaluated. Although no macroscopic reducting effect of TAM on tumors was found, proliferation and replacement of connective tissue and the expansion of central necrosis was observed histologically. The administration of TAM (2.0mg/kg) caused a tendency to decrease S-phase cells and increase G0/G1-phase cells. These findings indicate that TAM might inhibit DNA syntheses. TAM significantly increased apoptosis cell in the Sub-G1 region on DNA cytograms in a dose-dependent manner. TAM is therefore thought to have a potentially inhibitory effect on the growth of ovarian cancer.
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Research Products
(25 results)
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[Journal Article] Vaccination with pre-designated or evidence-based peptides for patients with recurrent gynecologic cancers.2004
Author(s)
Tsuda N, Mochizuki K, Harada M, Sukehiro A, Kawano Koichiro, Yaniada A, Ushijima K, Sugiyama T, Nishida T, Yamada H, Itoh K, Kamura T.
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Journal Title
J Immunother 27
Pages: 60-72
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prognosis of patients with operable stage IB cervical cancer not undergoing class III radical hysterectomy.2002
Author(s)
Ishikawa H, Fujiwara K, Mikami Y, Kohno I, Shinozuka T, Yoshida N, Nishida M, Aoki Y, Miyagi Y, Sugiyama T, Kigawa J.
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Journal Title
J Clin Oncol 21
Pages: 171b(#2503)
Description
「研究成果報告書概要(欧文)」より
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