Investigation of gene and/or protein expression associated with recovery and/or regeneration of skeletal muscle from growth inhibition or damage

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 15200049
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Osaka University
• Principal Investigator: OHIRA Yoshinobu Graduate School of Medicine, Osaka University, Professor, 医学系研究科, 教授 (50185378)
• Co-Investigator(Kenkyū-buntansha): KAWANO Fuminori Graduate School of Medicine, Osaka University, Assistant, 医学系研究科, 助手 (90346156) ; OHMI Shinobu Institute of Medical Science, University of Tokyo, Associate Professor, 医科学研究所, 助教授 (20160046) ; OHIRA Yoshinobu Graduate School of Medicine, Osaka University, Professor (50185378)
• Project Period (FY): 2003 – 2006
• Keywords: Skeletal muscle / Immune function / Proteomics / Regeneration

Research Abstract

It has been well-known that the decreases of morphological and/or functional properties of skeletal muscles, caused by growth retardation, injury, long-term bedrest, spaceflight, or aging, inhibit the quality of life in daily life. Therefore, it is essential to develop the suitable methodology for the promotion of recovery and/or regeneration of muscles with inhibited properties or injury. Role(s) of interleukin-6 (IL-6), macrophage, satellite cell, and mechanical and/or metabolic stimuli in the regulation of muscular properties in response to damage or regeneration were studied. As the results, it was suggested that satellite cells play one of the key roles in the plasticity of muscle. The number and activity of satellite cells were decreased in muscle with atrophy or damage. On the contrary, data indicated that the recoveries of these parameters are essential for the regeneration of muscle. It was also suggested that the number and activity of satellite cells are regulated by mechanical stimuli, heat stress, IL-6, and macrophage. Further, it was indicated that the responses of gene and protein expression in rat soleus muscle to growth retardation, caused by gravitational unloading, and recovery in 1-G environment did not always coincide.

Research Products

• [Journal Article] Heat-stress facilitates the regeneration of injured skeletal muscle in rats. (2007)
  • Author(s): Kojima, A., K.Goto, S.Morioka, T.Naito, T.Akema, H.Fujiya, T.Sugiura, Y.Ohira, M.Beppu, H.Aoki, T.Yoshioka
  • Journal Title: J. Orthopaed. Sci. 12 Pages: 74-82
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transcription regulation of gene expression in rat brown adipose tissue in response to unloading or 2G loading during growing period. (2007)
  • Author(s): Watanabe, S., Y.Hitomi, F.Kawano, Y.Ohira, T.Kizaki, N.Nakano, T.Sakurai, T.Izawa, K.Suzuki, M.Sudoh, R.R.Roy, H.Ohno
  • Journal Title: Acta Astronautica 60 Pages: 889-898
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Heat-stress facilitates the regeneration of injured skeletal muscle in rats. (2007)
  • Author(s): Kojima, A., K.Goto, S.Morioka, T.Naito, T.Akema, H.Fujiya, T.Sugiura, Y.Ohira, M.Beppu, H.Aoki, T.Yoshioka.
  • Journal Title: J.Orthopaed.Sci. 12 Pages: 74-82
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transcription regulation of gene expression in rat brown adipose tissue in response to unloading or 2G loading during growing period. (2007)
  • Author(s): Watanabe, S., Y.Hitomi, F.Kawano, Y.Ohira, T.Kizaki, N.Nakano, T.Sakurai, T.Izawa, K.Suzuki, M.Sudoh, R.R.Roy, H.Ohno.
  • Journal Title: Acta Astronautica 60 Pages: 889-898
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanical load-dependent regulation of satellite cell and fiber size in rat soleus muscle. (2006)
  • Author(s): Wang, X.D., F.Kawano, Y.Matsuoka, K.Fukunaga, M.Terada, M.Sudoh, A.Ishihara, Y.Ohira
  • Journal Title: Am. J. Physiol. Cell Physiol. 290 Pages: C981-C989
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Irreversible morphplogical changes in leg bone following chronic gravitational unloading of growing rats. (2006)
  • Author(s): Ohira, Y., F.Kawano, X.D.Wang, M.Sudoh, Y.Iwashita, H.J.Majima, I.Nonaka
  • Journal Title: Life Sci. 79 Pages: 686-694
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Leucine-induced activation of translational initiation is partly regulated by the branched-chain α-keto acid dehydrogenase complex in C2C12 cells. (2006)
  • Author(s): Nakai, N., Y.Shimomura, T.Tamura, N.Tamura, K.Hamada, F.Kawano, Y.Ohira
  • Journal Title: Biochem. Biophys. Res. Commun. 343 Pages: 1244-1250
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of neural and mechanical influences in maintaining normal fast and slow muscle properties. (2006)
  • Author(s): Ohira, Y., T.Yoshinaga, M.Ohara, F.Kawano, X.D.Wang, Y.Higo, M.Terada, Y.Matsuoka, R.R.Roy, V.R.Edgerton
  • Journal Title: Cells Tissues Organs 182 Pages: 129-142
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Comparison of cell body size and oxidative enzyme activity in motoneurons between the cervical and lumber segments in the rat spinal cord after spaceflight and recovery. (2006)
  • Author(s): Ishihara, A., J.Yamashiro, A.Matsumoto, A.Higashibata, N.Ishioka, T.Shimazu, Y.Ohira
  • Journal Title: Neurochem. Res. 31 Pages: 411-415
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Comparison of cell body size and oxidative enzyme activity in motoneurons between the cervical and lumbar segments in the spinal cord after spaceflight and recovery. (2006)
  • Author(s): Matsumoto, A., F.Kawano, A.Higashibata, N.Ishioka, T.Shimazu, Y.Ohira, A.Ishihara
  • Journal Title: J. Gravit. Physiol. 13 Pages: 11-12
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of acute exposure to microgravity or hypergravity environment on motor control of arm in human. (2006)
  • Author(s): Terada, M., F.Kawano, X.D.Wang, Y.Matsuoka, T.Ochiai, H.Inada, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 13 Pages: 33-34
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of macrophage function in regeneration of soleus muscle fibers in op/op mice. (2006)
  • Author(s): Wang, X.D., F.Kawano, Y.Matsuoka, M.Terada, H.Yamamoto, T.Ito, K.Goto, Y.B.Lan, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 13 Pages: 77-78
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Responses of adductor longus muscle to hindlimb suspension in Wistar Hannover rats. (2006)
  • Author(s): Ohira, T., S.Morikuni, X.D.Wang, M.Terada, F.Kawano, Y.Matsuoka, Y.Higo, Y.B.Lan, T.Seki, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 13 Pages: 79-80
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role(s) of macrophage in the plasticity of plantaris muscle fibers in op/op mice. (2006)
  • Author(s): Morikuni, S., T.Ohira, X.D.Wang, M.Terada, F.Kawano, Y.Matsuoka, Y.B.Lan, H.Yamamoto, T.Ito, K.Goto, T.Seki, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 13 Pages: 81-82
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Blockade of inerleukin-6 signaling pathway promotes muscle cell differentiation. (2006)
  • Author(s): Matsuoka, Y., F.Kawano, X.D.Wang, M.Terada, Y.Higo, Y.B.Lan, A.Ogura, N.Nishimoto, Y.Adachi, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 13 Pages: 83-84
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanical stress-dependent transformation of nucleoli in myonuclei of rat soleus muscle fibers. (2006)
  • Author(s): Kawano, F., Y.Matsuoka, Y.Oke, Y.Higo, M.Terada, X.D.Wang, Y.B.Lan, N.Nakai, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 13 Pages: 85-86
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of tenotomy and/or denervation on the characteristics of plantaris muscle fibers of mdx mice. (2006)
  • Author(s): Higo, Y., M.Terada, S.Umemoto, N.Kawabe, F.Kawano, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 13 Pages: 87-88
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Change of bone mineral and morphology in growing rat leg bone after hindlimb unloading. (2006)
  • Author(s): Majima, H.J., Y.Iwashita, A.Higashibata, N.Ishioka, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 13 Pages: 91-92
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role(s) of gravitational loading on the transcription regulation of gene expression in rat brown adipose tissue during growing period. (2006)
  • Author(s): Ohira, Y., S.Watanabe, Y.Hitomi, F.Kawano, T.Kizaki, N.Nakano, T.Sakurai, T.Izawa, K.Suzuki, M.Sudoh, R.R.Roy, H.Ohno
  • Journal Title: J. Gravit. Physiol. 13 Pages: 151-152
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanical load-dependent regulation of satellite cell and fiber size in rat soleus muscle. (2006)
  • Author(s): Wang, X.D., F.Kawano, Y.Matsuoka, K.Fukunaga, M.Terada, M.Sudoh, A.Ishihara, Y.Ohira.
  • Journal Title: Am.J.Physiol.Cell Physiol. 290 Pages: C981-C989
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Irreversible morphplogical changes in leg bone following chronic gravitational unloading of growing rats. (2006)
  • Author(s): Ohira, Y., F.Kawano, X.D.Wang, M.Sudoh, Y.Iwashita, H.J.Majima, I.Nonaka.
  • Journal Title: Life Sci. 79 Pages: 686-694
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Leucine-induced activation of translational initiation is partly regulated by the branched-chain α-keto acid dehydrogenase complex in C2C12 cells. (2006)
  • Author(s): Nakai, N., Y.Shimomura, T.Tamura, N.Tamura, K.Hamada, F.Kawano, Y.Ohira.
  • Journal Title: Biochem.Biophys.Res.Commun. 343 Pages: 1244-1250
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of neural and mechanical influences in maintaining normal fast and slow muscle properties. (2006)
  • Author(s): Ohira, Y., T.Yoshinaga, M.Ohara, F.Kawano, X.D.Wang, Y.Higo, M.Terada, Y.Matsuoka, R.R.Roy, Y.R.Edgerton.
  • Journal Title: Cells Tissues Organs 182 Pages: 129-142
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of cell body size and oxidative enzyme activity in motoneurons between the cervical and lumber segments in the rat spinal cord after spaceflight and recovery. (2006)
  • Author(s): Ishihara, A., J.Yamashiro, A.Matsumoto, A.Higashibata, N.Ishioka, T.Shimazu, Y.Ohira.
  • Journal Title: Neurochem.Res 31 Pages: 411-415
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of cell body size and oxidative enzyme activity in motoneurons between the cervical and lumbar segments in the spinal cord after spaceflight and recovery. (2006)
  • Author(s): Matsumoto, A., F.Kawano, A.Higashibata, N.Ishioka, T.Shimazu, Y.Ohira, A.Ishihara.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 11-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of acute exposure to microgravity or hypergravity environment on motor control of arm in human. (2006)
  • Author(s): Terada, M., F.Kawano, X.D.Wang, Y.Matsuoka, T.Ochiai, H.Inada, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 33-34
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of macrophage function in regeneration of soleus muscle fibers in op/op mice. (2006)
  • Author(s): Wang, X.D., F.Kawano, Y.Matsuoka, M.Terada, H.Yamamoto, T.Ito, K.Goto, Y.B.Lan, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 77-78
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Responses of adductor longus muscle to hindlimb suspension in Wistar Hannover rats. (2006)
  • Author(s): Ohira, T, S.Morikuni, X.D.Wang, M.Terada, F.Kawano, Y.Matsuoka, Y.Higo, Y.B.Lan, T.Seki, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 79-80
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role(s) of macrophage in the plasticity of plantaris muscle fibers in op/op mice. (2006)
  • Author(s): Morikuni, S., T.Ohira, X.D.Wang, M.Terada, F.Kawano, Y.Matsuoka, Y.B.Lan, H.Yamamoto, T.Ito, K.Goto, T.Seki, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 81-82
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of inerleukin-6 signaling pathway promotes muscle cell differentiation. (2006)
  • Author(s): Matsuoka, Y., F.Kawano, X.D.Wang, M.Terada, Y.Higo, Y.B.Lan, A.Ogura, N.Nishimoto, Y.Adachi, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 83-84
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanical stress-dependent transformation of nucleoli in myonuclei of rat soleus muscle fibers. (2006)
  • Author(s): Kawano, F., Y.Matsuoka, Y.Oke, Y.Higo, M.Terada, X.D.Wang, Y.B.Lan, N.Nakai, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 85-86
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of tenotomy and/or denervation on the characteristics of plantaris muscle fibers of mdx mice. (2006)
  • Author(s): Higo, Y., M.Terada, S.Umemoto, N.Kawabe, F.Kawano, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 87-88
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Change of bone mineral and morphology in growing rat leg bone after hindlimb unloading. (2006)
  • Author(s): Majima, H.J., Y.Iwashita, A.Higashibata, N.Ishioka, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 91-92
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role(s) of gravitational loading on the transcription regulation of gene expression in rat brown adipose tissue during growing period. (2006)
  • Author(s): Ohira, Y., S.Watanabe, Y.Hitomi, F.Kawano, T.Kizaki, N.Nakano, T.Sakurai, T.Izawa, K.Suzuki, M.Sudoh, R.R.Roy, H.Ohno.
  • Journal Title: J.Gravit.Physiol. 13 Pages: 151-152
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hyperbaric exposure with high oxygen concentration enhances oxidative capacity of neuromuscular units. (2005)
  • Author(s): Ishihara, A., F.Kawano, T.Okiura, F.Morimatsu, Y.Ohira
  • Journal Title: Neurosci. Res. 52 Pages: 146-152
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Calcineurin and heat shock protein 72 in functionally overloaded rat plantaris muscle. (2005)
  • Author(s): Oishi, Y., T.Ogata, Y.Ohira, K.Taniguchi, R.R.Roy
  • Journal Title: Biochem. Biophys. Res. Commun. 330 Pages: 706-713
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Possible role of calcineurin in heating-related increase of rat muscle mass. (2005)
  • Author(s): Kobayashi, T., K.Goto, A.Kojima, T.Akema, K.Uehara, H.Aoki, T.Sugiura, Y.Ohira, T.Yoshioka
  • Journal Title: Biochem. Biophys. Res. Commun. 331 Pages: 1301-1309
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of cold-water immersion on VEGF mRNA and protein expression in heart and skeletal muscles of rats. (2005)
  • Author(s): Kim, J.C., H.K.Yi, P.H.Hwang, J.S.Yoon, H.J.Kim, F.Kawano, Y.Ohira, C.K.Kim
  • Journal Title: Acta Physiol. Scand. 183 Pages: 389-397
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Heat stress as a countermeasure for prevention of muscle atrophy in microgravity environment. (2005)
  • Author(s): Goto, K., A.Kojima, T.Kobayashi, K.Uehara, S.Morioka, T.Naito, T.Akema, T.Sugiura, Y.Ohira, T.Yoshioka
  • Journal Title: Jpn. J. Aerospace Environ. Med. 42 Pages: 51-59
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Different responses in soleus muscle fibers of Wistar and Wistar Hannover rats to hindlimb unloading. (2005)
  • Author(s): Wang, X.D., F.Kawano, M.Terada, Y.Matsuoka, Y.Shinoda, A.Ishihara, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 12 Pages: 131-132
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of afferent input and mechanical load for size regulation of rat soleus muscle. (2005)
  • Author(s): Kawano, F., Y.Matsuoka, Y.Oke, Y.Higo, M.Terada, S.Umemoto, N.Kawabe, X.D.Wang, Y.Shinoda, Y.B.Lan, H.Fukuda, S.Ohmi, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 12 Pages: 133-134
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mechanical and/or neural activity-dependent regulation of soleus muscle fibers of mdx mice. (2005)
  • Author(s): Terada, M., F.Kawano, Y.B.Lan, Y.Matsuoka, X.D.Wang, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 12 Pages: 135-136
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] How does the nucleolar number involve in muscle fiber atrophy? Response to β-guanidinopropionic acid supplementation. (2005)
  • Author(s): Matsuoka, Y., F.Kawano, Y.Oke, Y.Higo, S.Umemoto, N.Kawabe, X.D.Wang, M.Terada, Y.Shinoda, Y.B.Lan, A.Ishihara, Y.Ohira
  • Journal Title: J. Gravit. Physiol. 12 Pages: 147-148
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hyperbaric exposure with high oxygen concentration enhances oxidative capacity of neuromuscular units. (2005)
  • Author(s): Ishihara, A., F.Kawano, T.Okiura, F.Morimatsu, Y.Ohira.
  • Journal Title: Neurosci.Res. 52 Pages: 146-152
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Calcineurin and heat shock protein 72 in functionally overloaded rat plantaris muscle. (2005)
  • Author(s): Oishi, Y., T.Ogata, Y.Ohira, K.Taniguchi, R.R.Roy.
  • Journal Title: Biochem.Biophys.Res.Commun. 330 Pages: 706-713
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Possible role of calcineurin in heating-related increase of rat muscle mass. (2005)
  • Author(s): Kobayashi, T., K.Goto, A.Kojima, T.Akema, K.Uehara, H.Aoki, T.Sugiura, Y.Ohira, T.Yoshioka.
  • Journal Title: Biochem.Biophys.Res.Commun. 331 Pages: 1301-1309
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of cold-water immersion on VEGF mRNA and protein expression in heart and skeletal muscles of rats. (2005)
  • Author(s): Kim, J.C., H.K.Yi, P.H.Hwang, J.S.Yoon, H.J.Kim, F.Kawano, Y.Ohira, C.K.Kim.
  • Journal Title: Acta Physiol.Scand 183 Pages: 389-397
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heat stress as a countermeasure for prevention of muscle atrophy in microgravity environment. (2005)
  • Author(s): Goto, K., A.Kojima, T.Kobayashi, K.Uehara, S.Morioka, T.Naito, T.Akema, T.Sugiura, Y.Ohira, T.Yoshioka.
  • Journal Title: Jpn.J.Aerospace Environ.Med. 42 Pages: 51-59
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Different responses in soleus muscle fibers of Wistar and Wistar Hannover rats to hindlimb unloading. (2005)
  • Author(s): Wang, X.D., F.Kawano, M.Terada, Y.Matsuoka, Y.Shinoda, A.Ishihara, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 12 Pages: 131-132
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of afferent input and mechanical load for size regulation of rat soleus muscle. (2005)
  • Author(s): Kawano, F., Y.Matsuoka, Y.Oke, Y.Higo, M.Terada, S.Umemoto, N.Kawabe, X.D.Wang, Y.Shinoda, Y.B.Lan, H.Fukuda, S.Ohmi, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 12 Pages: 133-134
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanical and/or neural activity-dependent regulation of soleus muscle fibers of mdx mice. (2005)
  • Author(s): Terada, M., F.Kawano, Y.B.Lan, Y.Matsuoka, X.D.Wang, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 12 Pages: 135-136
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] How does the nucleolar number involve in muscle fiber atrophy? Response toβ-guanidinopropionic acid supplementation. (2005)
  • Author(s): Matsuoka, Y., F.Kawano, Y.Oke, Y.Higo, S.Umemoto, N.Kawabe, X.D.Wang, M.Terada, Y.Shinoda, Y.B.Lan, A.Ishihara, Y.Ohira.
  • Journal Title: J.Gravit.Physiol. 12 Pages: 147-148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tension- and afferent-input-associated responses of neuromuscular system of rats to hindlimb unloading and/or tenotomy. (2004)
  • Author(s): Kawano, F., A.Ishihara, J.L.Stevens, X.D.Wang, S.Ohshima, M.Horisaka, Y.Maeda, I.Nonaka, Y.Ohira
  • Journal Title: Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 Pages: R76-R86
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hindlimb suspension inhibits air-righting due to altered recruitment of neck and back muscles in rats. (2004)
  • Author(s): Kawano, F., X.D.Wang, Y.B.Lan, H.Yonemitsu, A.Ishihara, M.Igarashi, Y.Ohira
  • Journal Title: Jpn. J. Physiol. 54 Pages: 229-242
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Heat-stress enhances proliferative potensial in rat soleus muscle. (2004)
  • Author(s): Uehara, K., K.Goto, T.Kobayashi, A.Kojima, T.Akema, T.Sugiura, S.Yamada, Y.Ohira, T.Yoshioka, H.Aoki
  • Journal Title: Jpn. J. Physiol. 54 Pages: 263-271
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Heat stress facilitates the recovery of atrophied soleus muscle in rat. (2004)
  • Author(s): Goto, K., M.Honda, T.Kobayashi, K.Uehara, A.Kojima, T.Akema, T.Sugiura, S.Yamada, Y.Ohira, T.Yoshioka
  • Journal Title: Jpn. J. Physiol. 54 Pages: 285-293
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of running exercise during recovery from hindlimb unloading on soleus muscle fibers and their spinal motoneurons in rats. (2004)
  • Author(s): Ishihara, A., F.Kawano, N.Ishioka, H.Oishi, A.Higashibata, T.Shimazu, Y.Ohira
  • Journal Title: Neurosci. Res. 48 Pages: 119-127
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of 20-week intermittent cold-water-immersion on phenotype and myonuclei in single fibers of rat hindlimb muscles. (2004)
  • Author(s): Lee, J.H., E.Y.Han, M.S.Kang, F.Kawano, H.J.Kim, Y.Ohira, C.K.Kim
  • Journal Title: Jpn. J. Physiol. 54 Pages: 331-337
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of gravity in mammalian development : effects of hypergravity and/or microgravity on the development of skeletal muscles. (2004)
  • Author(s): Ohira, Y., F.Kawano, K.Goto, X.D.Wang, Y.Takeno, A.Ishihara
  • Journal Title: Biol. Sci. Space 18 Pages: 124-125
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Load-dependent regulation of neuromuscular system. (2004)
  • Author(s): Ohira, Y., F.Kawano, A.Ishihara
  • Journal Title: J. Gravit. Physiol. 11 Pages: 127-128
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Tension-and afferent-input-associated responses of neuromuscular system of rats to hindlimb unloading and/or tenotomy. (2004)
  • Author(s): Kawano, F., A.Ishihara, J.L.Stevens, X.D.Wang, S.Ohshima, M.Horisaka, Y.Maeda, I.Nonaka, Y.Ohira.
  • Journal Title: Am.J.Physiol.Regul.Integr.Comp.Physiol. 287 Pages: R76-R86
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hindlimb suspension inhibits air-righting due to altered recruitment of neck and back muscles in rats. (2004)
  • Author(s): Kawano, F., X.D.Wang, Y.B.Lan, H.Yonemitsu, A.Ishihara, M.Igarashi, Y.Ohira.
  • Journal Title: Jpn.J.Physiol. 54 Pages: 229-242
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heat-stress enhances proliferative potensial in rat soleus muscle. (2004)
  • Author(s): Uehara, K., K.Goto, T.Kobayashi, A.Kojima, T.Akema, T.Sugiura, S.Yamada, Y.Ohira, T.Yoshioka, H.Aoki.
  • Journal Title: Jpn.J.Physiol. 54 Pages: 263-271
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heat stress facilitates the recovery of atrophied soleus muscle in rat. (2004)
  • Author(s): Goto, K., M.Honda, T.Kobayashi, K.Uehara, A.Kojima, T.Akema, T.Sugiura, S.Yamada, Y.Ohira, T.Yoshioka.
  • Journal Title: Jpn.J.Physiol. 54 Pages: 285-293
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of running exercise during recovery from hindlimb unloading on soleus muscle fibers and their spinal motoneurons in rats. (2004)
  • Author(s): Ishihara, A., F.Kawano, N.Ishioka, H.Oishi, A.Higashibata, T.Shimazu, Y.Ohira.
  • Journal Title: Neurosci.Res. 48 Pages: 119-127
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of 20-week intermittent cold-water-immersion on phenotype and myonuclei in single fibers of rat hindlimb muscles. (2004)
  • Author(s): Lee, J.H., E.Y.Han, M.S.Kang, F.Kawano, H.J.Kim, Y.Ohira, C.K.Kim.
  • Journal Title: Jpn.J.Physiol. 54 Pages: 331-337
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of gravity in mammalian development : effects of hypergravity and/or microgravity on the development of skeletal muscles. (2004)
  • Author(s): Ohira, Y., F.Kawano, K.Goto, X.D.Wang, Y.Takeno, A.Ishihara.
  • Journal Title: Biol. Sci. Space 18 Pages: 124-125
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Load-dependent regulation of neuromuscular system. (2004)
  • Author(s): Ohira, Y., F.Kawano, A.Ishihara.
  • Journal Title: J.Gravit.Physiol. 11 Pages: 127-128
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Metabolic modulation of muscle fiber properties unrelated to mechanical stimuli. (2003)
  • Author(s): Ohira, Y., F.Kawano, R.R.Roy, V.R.Edgerton.
  • Journal Title: Jpn. J. Physiol. 53 Pages: 389-400
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of heat stress and mechanical stretch on protein expression in cultured skeletal muscle cells. (2003)
  • Author(s): Goto, K., R.Okuyama, H.Sugiyama, M.Honda, T.Kobayashi, K.Uehara, T.Akema, T.Sugiura, S.Yamada, Y.Ohira, T.Yoshioka.
  • Journal Title: Pflugers Arch. - Eur. J. Physiol. 447 Pages: 247-253
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Motoneuron and sensory neuron plasticity to varying neuromuscular activity levels. (2003)
  • Author(s): Ishihara, A., R.R.Roy, Y.Ohira, V.R.Edgerton.
  • Journal Title: Exer. Sport Sci. Rev. 31 Pages: 51-57
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Profiles of connectin (titin) in atrophied soleus muscle induced by unloading of rats. (2003)
  • Author(s): Goto, K., R.Okuyama, M.Honda, H.Uchida, T.Akema, Y.Ohira, T.Yoshioka
  • Journal Title: J. Appl. Physiol. 94 Pages: 897-902
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of aging and exercise on density and cross-sectional area of femur in senescence-accelerated mouse prone 6. (2003)
  • Author(s): Ishihara, A., R.R.Roy, Y.Ohira, F.Kawano, K.Nonaka, K.Yamamoto, V.R.Edgerton
  • Journal Title: J. Musculoskel. Neuron. Interact. 3 Pages: 162-169
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Upregulation of HSP72 in reloading rat soleus muscle after prolonged hindlimb unloading. (2003)
  • Author(s): Oishi, Y., K.Taniguchi, H.Matsumoto, F.Kawano, A.Ishihara, Y.Ohira
  • Journal Title: Jpn. J. Physiol. 53 Pages: 281-286
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential responses of HSPs to heat stress in slow and fast regions of rat gastrocnemius muscle. (2003)
  • Author(s): Oishi, Y., K.Taniguchi, H.Matsumoto, A.Ishihara, Y.Ohira, R.R.Roy
  • Journal Title: Muscle ＆ Nerve 28 Pages: 587-594
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Metabolic modulation of muscle fiber properties unrelated to mechanical stimuli. (2003)
  • Author(s): Ohira, Y, F.Kawano, R.R.Roy, V.R.Edgerton.
  • Journal Title: Jpn.J.Physiol. 53 Pages: 389-400
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of heat stress and mechanical stretch on protein expression in cultured skeletal muscle cells. (2003)
  • Author(s): Goto, K., R.Okuyama, H.Sugiyama, M.Honda, T.Kobayashi, K.Uehara, T.Akema, T.Sugiura, S.Yamada, Y.Ohira, T.Yoshioka.
  • Journal Title: Pflugers Arch.-Eur.J.Physiol. 447 Pages: 247-253
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Motoneuron and sensory neuron plasticity to varying neuromuscular activity levels. (2003)
  • Author(s): Ishihara, A., R.R.Roy, Y.Ohira, V.R.Edgerton.
  • Journal Title: Exer.Sport Sci.Rev. 31 Pages: 51-57
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Profiles of connectin (titin) in atrophied soleus muscle induced by unloading of rats. (2003)
  • Author(s): Goto, K., R.Okuyama, M.Honda, H.Uchida, T.Akema, Y.Ohira, T.Yoshioka.
  • Journal Title: J.Appl.Physiol. 94 Pages: 897-902
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of aging and exercise on density and cross-sectional area of femur in senescence-accelerated mouse prone 6. (2003)
  • Author(s): Ishihara, A., R.R.Roy, Y.Ohira, F.Kawano, K.Nonaka, K.Yamamoto, V.R.Edgerton.
  • Journal Title: J.Musculoskel.Neuron.Interact. 3 Pages: 162-169
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Upregulation of HSP72 in reloading rat soleus muscle after prolonged hindlimb unloading. (2003)
  • Author(s): Oishi, Y., K.Taniguchi, H.Matsumoto, F.Kawano, A.Ishihara, Y.Ohira.
  • Journal Title: Jpn.J.Physiol. 53 Pages: 281-286
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential responses of HSPs to heat stress in slow and fast regions of rat gastrocnemius muscle. (2003)
  • Author(s): Oishi, Y., K.Taniguchi, H.Matsumoto, A.Ishihara, Y.Ohira, R.R.Roy.
  • Journal Title: Muscle ＆ Nerve 28 Pages: 587-594
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role(s) of nucleoli, phosphorylation of ribosomal protein S6 and/or HSP27 in the regulation of muscle mass.
  • Author(s): Kawano, F., Y.Matsuoka, Y.Oke, Y.Higo, M.Terada, X.D.Wang, N.Nakai, H.Fukuda, S.Imajoh-Ohmi, Y.Ohira
  • Journal Title: Am. J. Physiol. Cell Physiol. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of mechanical and neural stimuli on the properties of soleus muscle fibers in mdx mice.
  • Author(s): Lan, Y.B., M.Terada, Y.Higo, F.Kawano, Y.Matsuoka, X.D.Wang, N.Nakai, Y.Ohira
  • Journal Title: Jpn. J. Aerosp. Environ. Med. (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Investigation of the mechanism responsible for muscle atrophy and countermeasures in microgravity environment : Role(s) of mechanical load and/or satellite cells.
  • Author(s): Ohira, Y., X.D.Wang, F.Kawano, M.Terada, Y.Matsuoka, Y.Higo, T.Ohira, A.Kojima, K.Goto, T.Yoshioka
  • Journal Title: Proceedings for the International Symposium on Space Medicine, Sapporo (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role(s) of nucleoli, phosphorylation of ribosomal protein S6 and/or HSP27 in the regulation of muscle mass.
  • Author(s): Kawano, F., Y.Matsuoka, Y.Oke, Y.Higo, M.Terada, X.D.Wang, N.Nakai, H.Fukuda, S.Imajoh-Ohmi, Y.Ohira.
  • Journal Title: Am.J.Physiol.Cell Physiol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of mechanical and neural stimuli on the properties of soleus muscle fibers in mdx mice.
  • Author(s): Lan, Y.B., M.Terada, Y.Higo, F.Kawano, Y.Matsuoka, X.D.Wang, N.Nakai, Y.Ohira.
  • Journal Title: Jpn.J.Aerosp.Environ.Med. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Investigation of the mechanism responsible for muscle atrophy and countermeasures in microgravity environment : Role(s) of mechanical load and/or satellite cells.
  • Author(s): Ohira, Y., X.D.Wang, F.Kawano, M.Terada, Y.Matsuoka, Y.Higo, T.Ohira, A.Kojima, K.Goto, T.Yoshioka.
  • Journal Title: Proceedings for the International Symposium on Space Medicine, Sapporo (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 宇宙飛行士の体力。体力とはなにか-運動処方のその前に-(長澤純一(編)) (2007)
  • Author(s): 大平充宣
  • Total Pages: 119-126
  • Publisher: ナップ
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 重力と気圧 : 宇宙。「環境生理学」(本間研一・彼末一之・編) (2007)
  • Author(s): 大平充宣, 関口千春, 石井正則, 石原昭彦
  • Total Pages: 245-260
  • Publisher: 北海道大学出版会
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 微小重力環境への神経・筋の適応。生産と技術 58(3) (2006)
  • Author(s): 大平充宣
  • Total Pages: 54-57
  • Publisher: 社団法人生産技術振興協会
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 微小重力環境での運動。学術の動向 10 (2006)
  • Author(s): 大平充宣
  • Total Pages: 58-63
  • Publisher: 日本学術会議
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 血液。生活習慣病対策および健康維持・増進のための運動療法と運動処方。(監修 : 佐藤祐造) (2005)
  • Author(s): 大平充宣
  • Total Pages: 45-49
  • Publisher: 文光堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 身体能力の老化。(現代 老年精神医療、武田雅俊(編)) (2005)
  • Author(s): 後藤勝正, 大平充宣
  • Total Pages: 82-89
  • Publisher: 永井書店
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 加齢および廃用性筋萎縮と予防策。The Bone l9 (2005)
  • Author(s): 後藤勝正, 大平充宣
  • Total Pages: 113-117
  • Publisher: メディカルレビュー社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 無重力環境への神経・筋の適応 (2004)
  • Author(s): 大平充宣, 河野史倫, 王暁東, 石原昭彦
  • Total Pages: 83-87
  • Publisher: 日本マイクログラビティ学会
  • Description: 「研究成果報告書概要(和文)」より