Interorgan communication governing neuronal cell growth under distinct nutrient conditions

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02400
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Kyoto University
• Principal Investigator: Uemura Tadashi 京都大学, 生命科学研究科, 教授 (80213396)
• Co-Investigator(Renkei-kenkyūsha): HATTORI Yukako 京都大学, 大学院生命科学研究科, 助教 (50646768)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 器官形成 / 栄養 / 神経細胞 / 樹状突起 / 器官間相互作用

Outline of Final Research Achievements

We addressed how neuronal growth is controlled by nutritional status using Class IV dendritic arborization neurons in Drosophila larvae. We found that dendritic arbors of Class IV neurons became more complex when larvae were reared on a low-yeast diet, which contains lower amounts of amino acids and other ingredients, compared to a high-yeast diet. We also showed that mitochondrial dysfunction triggers dendritic loss in a manner dependent on eIF2α phosphorylation and translation inhibition.

Free Research Field

栄養発生生物学