Effects of S-equol on the development of of type 2 diabetes mellitus

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02900
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits
• Research Institution: Osaka Prefecture University
• Principal Investigator: Inui Hiroshi 大阪府立大学, 総合リハビリテーション学研究科, 教授 (20193568)
• Co-Investigator(Kenkyū-buntansha): 原田 直樹 大阪府立大学, 生命環境科学研究科, 講師 (00529141) ; 甲斐 建次 大阪府立大学, 生命環境科学研究科, 講師 (40508404)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: S-エクオール / 膵β細胞 / 糖尿病 / cAMP/PKAシグナル / ストレプトゾトシン

Outline of Final Research Achievements

In the present study, we show that S-equol increased pancreatic beta-cell growth, viability, and insulin secretion through activation of G-protein coupled receptor (Gs class). Administration of S-equol suppressed against streptozotocin-induced hyperglycemia by preserving beta-cell mass in mice. These results suggest that S-equol may be useful for an anti-type 2 diabetic agent.

Free Research Field

代謝栄養学