Functional and genetical study on protein leakage from glomeruli at the early stage of diabetes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03012
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kawasaki Medical School
• Principal Investigator: Nakamoto Hiroshi 川崎医科大学, 医学部, 助教 (10299183)
• Co-Investigator(Kenkyū-buntansha): 矢田 豊隆 川崎医科大学, 医学部, 講師 (00210279) ; 小笠原 康夫 川崎医療福祉大学, 医療技術学部, 教授 (10152365)
• Co-Investigator(Renkei-kenkyūsha): Kajiya Fumihiko 川崎医療福祉大学, 医療技術学部, 教授 (70029114)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病 / 糸球体濾過 / スリット膜 / NO / ネフリン

Outline of Final Research Achievements

The purpose of this study is to elucidate the mechanism how C-peptide correct the hyperfiltration and protein leakage from the glomerulus at the early stage of diabetes in a rat. C-peptide did not affect the expression of nephrin, one　of the component proteins of slit membrane. The effect of C-peptide towards iNOS, IL-6, CRP, EPO and VEGF was also examined. The only difference we found was that iNOS concentration was decreased by C-peptide administration. The reduction of iNOS may have contributed to correcting the hyperfiltration and protein leakage from the glomerulus. C-peptide, is considered, affects the rodent glomeruli functionally but not structurally.

Free Research Field

微小循環生理