Protective impact of exercise on appearance of metabolic syndrome via changes in gut microbiota

2018 Fiscal Year Final Research Report

• Project/Area Number: 15H03102
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kawasaki University of Medical Welfare
• Principal Investigator: Yano Hiromi 川崎医療福祉大学, 医療技術学部, 教授 (20248272)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 自発運動 / TLR5遺伝子欠損マウス / 高脂肪食 / 肥満症 / F/B比

Outline of Final Research Achievements

To clarify the possibility of the preventive effects of exercise habits on metabolic syndrome through a change in the intestinal microbiota, exercise-induced changes in intestinal microbiota in mice lacking Toll-like receptor 5 (TLR5) ), which develop metabolic syndrome, were investigated. The indicators of metabolic syndrome, which were observed in the gene knockout mice were attenuated by treatment of wheel-running. In addition, the knockout mice treated wheel-running showed both inhibition of chronic inflammation and changes in intestinal microbiota. These results suggest that voluntary exercise may be able to control the regulation of intestinal microbiota via TLR5 associated with deterioration of the metabolic syndrome.

Free Research Field

運動免疫学

Academic Significance and Societal Importance of the Research Achievements

メタボリックシンドローム予防効果を検討した便移植実験例は報告されていない。しかし、運動習慣を有するドナーマウスからの便移植による、レシピエントマウスの体重抑制現象を観察した。便移植による肥満が解消されるという結果は、運動習慣による腸内細菌叢の改善効果を示唆するという点で、意義ある知見かもしれない。今後、アスリートの腸内細菌叢研究、さらにはサプリメントとして健康産業界へ参入してくる将来への可能性を予感させるものと考える。