Development of next-generation wireless-electroless oscillator biosensors for diagnosis and drug development

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03587
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General applied physics
• Research Institution: Osaka University
• Principal Investigator: Ogi Hirotsugu 大阪大学, 工学研究科, 教授 (90252626)
• Co-Investigator(Kenkyū-buntansha): 南野 哲男 香川大学, 医学部, 教授 (30379234) ; 後藤 祐児 大阪大学, たんぱく質研究所, 教授 (40153770) ; 中村 暢伴 大阪大学, 基礎工学研究科, 助教 (50452404)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: QCM / バイオセンサー / 蛋白質相互作用 / 無線

Outline of Final Research Achievements

We have developed MEMS quartz-crystal-microbalance biosensors and succeeded in improving the stability and sensitivity. The high-frequency biosensors allowed us to detect target proteins even in a solution with impurity proteins whose concentrations were much higher than that of target protein. The viscoelasticity was successfully monitored during the structural transduction of Amyloid beta peptide using higher vibrational modes. Furthermore, combination of the wireless-electrodeless QCM in the total internal reflection fluorescence microscopy revealed novel properties of fibrillation of the papeitdes.

Free Research Field

超音波工学