Evaluation of Liver flow dynamics for organ preservation, recovery and assessment to develop future medical devices

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03922
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: obara Hiromichi 首都大学東京, 理工学研究科, 准教授 (80305424)
• Co-Investigator(Kenkyū-buntansha): 松野 直徒 旭川医科大学, 医学部, 特任教授 (00231598)
• Co-Investigator(Renkei-kenkyūsha): Enosawa Shin 国立成育医療研究センター, 研究所, 室長 (40232962) ; HIRANO Toshihiko 東京薬科大学, 薬学部, 教授 (90173252)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 臓器移植 / 臓器工学 / 機械灌流 / 機能評価 / 灌流保存

Outline of Final Research Achievements

Technology for an organ preservation, recovery and assessment is very important to develop future medical devices to enhance organ quality for transplantation. The use of organ donated after cardiac death (DCD) treated with the future medical device would greatly contribute to expansion of the donor organ pool. Machine perfusion (MP) is a promising technology to preserve the organ function and improve the organ quality of the DCD. Furthermore, organ assessment with the MP is effective to treat DCD organ. Although several perfusion technologies under various conditions have been suggested, optimum condition and adequate technology are still debated. In particularly, there are few studies of the ex vivo liver flow dynamics under several MP condition. In this study, we evaluated the the ex vivo liver flow dynamics using micro and macro experimental approaches and numerical analysis.

Free Research Field

流体工学，医用工学，臓器工学