2017 Fiscal Year Final Research Report
Cytoskeleton mechanisms of activity-dependent axon branching
| Project/Area Number |
15H04260
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菅生 紀之 大阪大学, 生命機能研究科, 助教 (20372625)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 大脳皮質 / 軸索分岐 / RhoGEF / RhoA |
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| Outline of Final Research Achievements |
Axon branching is essential for neuronal circuit formation. In the present study, we investigated the role of Rho guanine nucleotide exchange factor (RhoGEF) in axon branch formation in developing cortical neurons. The results demonstrated that multiple RhoGEFs are expressed in the mammalian cortex and are differentially involved in axon branching of cortical neurons via the RhoA pathway.
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| Free Research Field |
神経科学
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