2017 Fiscal Year Final Research Report
Development of high-efficiency gene targeting technologies
| Project/Area Number |
15H04323
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
System genome science
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
Noritaka Adachi 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 (30264675)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | ジーンターゲティング / ヒトゲノム / ゲノム編集 / DNA修復 |
|---|
| Outline of Final Research Achievements |
In this research project, we have successfully identified a human protein that is essential for alternative end-joining, a minor pathway of DNA double-strand break repair. This discovery has led us to develop a unique system to suppress random integration of transfected DNA, making it possible to perform human cell gene targeting with 100% efficiency.
|
| Free Research Field |
分子生物学
|
