2017 Fiscal Year Final Research Report
Trial for determining the structure of CXCR7
| Project/Area Number |
15H04338
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUGA Hiroaki 東京大学, 大学院理学研究科, 教授 (00361668)
YAMANAKA Yasuaki 京都大学, 大学院医学研究科, 研究員 (10724049)
NOMURA Norimichi 京都大学, 大学院医学研究科, 助教 (10314246)
FUJIWARA Takaaki 京都大学, 大学院医学研究科, 研究員 (70712751)
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| Research Collaborator |
IM Dohyun
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 結晶構造解析 / Gタンパク質共役型受容体 |
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| Outline of Final Research Achievements |
Chemokine receptor CXCR7 is a member of G protein coupled receptors (GPCR) and a potential drug target. CXCR7 is highly expressed in cancer cells and mediates tumor metastasis. Uniquely, CXCR7 does not couple to G protein but to beta-arrestin. The aim of this project is to determine the 3D structure of CXCR7. Currently, we have not succeeded to obtain crystals of CXCR7.
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| Free Research Field |
構造生物学
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