Regulation by orexigenic and anorexigenic neuropeptides of emotional behavior in fish

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04394
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: University of Toyama
• Principal Investigator: Matsuda Kouhei 富山大学, 大学院理工学研究部(理学), 教授 (60222303)
• Co-Investigator(Kenkyū-buntansha): 中町 智哉 富山大学, 大学院理工学研究部(理学), 助教 (30433840) ; 今野 紀文 富山大学, 大学院理工学研究部(理学), 講師 (50507051) ; 吉田 将之 広島大学, 生物圏科学研究科, 准教授 (70253119)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ゼブラフィッシュ / 情動行動 / キンギョ / メダカ / 摂食行動 / 神経基盤

Outline of Final Research Achievements

Our previous studies have indicated that intracerebroventricular (ICV) administration of several neuropeptides related to feeding regulation affect psychomotor activity in fish. Therefore, we examined the effect of ICV injection of neuropeptides such as cholecystokinin and pituitary adenylate cyclase-activating polypeptide (PACAP) on emotional behavior including anxiety-like behavior in fish. ICV administration of neuropeptides mentioned above induced anxiety-like behavior in fish. In addition, we prepared transgenic fish (including vasotosine, PACAP and mineralocorticoid-receptor knock out fish), and observed swimming behavior. The results suggested that psychomotor activity is affected by hormones- and their receptors-knock out.

Free Research Field

比較神経内分泌学