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2017 Fiscal Year Final Research Report

Analysis of inhibitory effect of food-derived substances inducing regulatory T cells and B cells on immune and inflammatory response and its molecular basis

Research Project

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Project/Area Number 15H04498
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionNippon Veterinary and Life Science University (2017)
The University of Tokyo (2015-2016)

Principal Investigator

Totsuka Mamoru  日本獣医生命科学大学, 応用生命科学部, 教授 (70227601)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywords制御性T細胞 / 制御性B細胞 / フィトケミカル / フラボノイド / 免疫抑制作用 / インターロイキン10 / 抗炎症効果
Outline of Final Research Achievements

Focusing on the immune-modulating functions of food factors, we searched for those inducing or activating regulatory T cells (Tregs) or regulatory B cells (Bregs), which have immune-suppressive functions. The mechanisms of action of the food factors and anti-inflammatory activity in vivo were investigated. We found several flavonoids having such an immune-modulating functions, and observed the suppressive effects of these factors on an animal model of inflammatory bowel diseases. Food factors with immune-suppressive functions are expected to prevent or ameliorate allergies and also lifestyle diseases developing on the basis of chronic inflammation.

Free Research Field

食品機能学、食品免疫学

URL: 

Published: 2019-03-29  

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