Analysis of inhibitory effect of food-derived substances inducing regulatory T cells and B cells on immune and inflammatory response and its molecular basis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04498
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Nippon Veterinary and Life Science University (2017); The University of Tokyo (2015-2016)
• Principal Investigator: Totsuka Mamoru 日本獣医生命科学大学, 応用生命科学部, 教授 (70227601)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 制御性Ｔ細胞 / 制御性B細胞 / フィトケミカル / フラボノイド / 免疫抑制作用 / インターロイキン10 / 抗炎症効果

Outline of Final Research Achievements

Focusing on the immune-modulating functions of food factors, we searched for those inducing or activating regulatory T cells (Tregs) or regulatory B cells (Bregs), which have immune-suppressive functions. The mechanisms of action of the food factors and anti-inflammatory activity in vivo were investigated. We found several flavonoids having such an immune-modulating functions, and observed the suppressive effects of these factors on an animal model of inflammatory bowel diseases. Food factors with immune-suppressive functions are expected to prevent or ameliorate allergies and also lifestyle diseases developing on the basis of chronic inflammation.

Free Research Field

食品機能学、食品免疫学