Influence of nutritional status on amino acid glycation in the chicken with high blood glucose

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04580
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Animal production science
• Research Institution: Iwate University
• Principal Investigator: Kita Kazumi 岩手大学, 農学部, 教授 (20221913)
• Co-Investigator(Kenkyū-buntansha): 西向 めぐみ 岩手大学, 農学部, 准教授 (40374730) ; 村岡 宏樹 岩手大学, 理工学部, 助教 (50546934) ; 平松 浩二 信州大学, 学術研究院農学系, 教授 (80238386)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖化反応 / ニワトリ / アマドリ化合物 / 栄養

Outline of Final Research Achievements

As chickens are hyperglycemic animals, amino acids bind non-enzymatically to glucose leading to form Amadori products. In this study, physiological roles of Amadori products in chickens were examined in vivo. When experimental diets containing various protein levels (crude protein 0%, 10%, 20% (Control), 40% and 60%) were given to young chickens, the ratio of plasma valine-Amadori product concentration to plasma valine concentration was significantly increased by the decrease in dietary crude protein levels. It was revealed that half-life of valine-Amadori product in the plasma was estimated to be 277 min by investigating the time course change of plasma valine-Amadori product concentration after intravenous administration of valine-Amadori product. Furthermore, it was shown that amino acid-Amadori product can be incorporated into chicken embryo derived cells.

Free Research Field

動物栄養学