2017 Fiscal Year Final Research Report
Elucidation of disease pathogenesis associated with dysregulated lipid metabolism and their potential therapeutic applications
| Project/Area Number |
15H04648
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Keio University (2016-2017)
Institute of Physical and Chemical Research (2015) |
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Principal Investigator |
ARITA Makoto 慶應義塾大学, 薬学部(芝共立), 教授 (80292952)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 脂質代謝 / 抗炎症作用 / リピドミクス / 生理活性物質 |
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| Outline of Final Research Achievements |
In this study, we identified omega-3 eicosapentaenoic acid (EPA)-derived bioactive metabolite, namely 17,18-EpETE, that possess anti-inflammatory and/or anti-allergic actions in vivo. Moreover, we identified cytochrome P450 (CYP) enzymes that play rate-limiting roles in controlling active conversion of EPA into 17,18-EpETE. These findings will elucidate the physiological importance of this metabolic pathway of omega-3 fatty acids in controlling inflammation and related diseases. Also we demonstrated the importance of fatty acid balance and their metabolic interactions in many disease models by using the advanced LC-MS/MS-based lipidomics system.
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| Free Research Field |
生物系薬学
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