Investigation of practical anticancer strategy based on chemically synthesized iRed/iPed

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04656
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: The University of Tokushima
• Principal Investigator: MINAKAWA Noriaki 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 (40209820)
• Co-Investigator(Kenkyū-buntansha): 石田 竜弘 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 (50325271) ; 阿部 洋 名古屋大学, 理学研究科, 教授 (80415067)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 核酸創薬 / DNAデバイス / 化学合成 / RNAi創薬

Outline of Final Research Achievements

In this study, research was conducted to further enhance the function of a DNA device (iRed) capable of expressing functional RNA in cells. As a result, (1) cyclization aimed at stabilizing iRed, (2) complete chemical synthesis of iRed, (3) searching for new cancer therapeutic drugs by combination with innovative delivery method, and (4) possibility to evolve this device to iPed expressing functional peptide peptide/protein were demonstrated.

Free Research Field

創薬化学