The development of epicutaneous allergen-specific immunotherapy for inducing food allergy resistance and the immunological analysis of it's response mechanisms

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04665
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Osaka University
• Principal Investigator: OKADA NAOKI 大阪大学, 薬学研究科, 教授 (90312123)
• Research Collaborator: ITO Sayami ; FUJISAWA Takao ; NAGAO Mizuho ; KUWABARA Yu ; KAMIYAMA Fumio ; QUAN Ying-Shu ; SAITO Mio ; ISHII Ken ; HIROBE Sachiko ; SUSAI Ryo ; TAKEUCHI Honoka ; EGUCHI Ryosuke ; LU lu ; NAKAGAWA Yusuke ; KAWAKITA Takuto
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アレルギー / 免疫療法 / 経皮投与

Outline of Final Research Achievements

Allergen-specific immunotherapy (AIT) is promising as a radical therapy for allergic diseases, and AIT is being accepted in food allergy. Currently, AIT is mainly performed by the subcutaneous injection (SCIT) which requires to visit a hospital for long time, and is difficult to continue the treatment for patients of children due to the injection pain. Thus, development of alternative administration route is required in AIT research field.
Skin has a high potential as a target site for AIT, because it not only function as a barrier to protect from foreign substances but also induces various immune responses. In the development of effective epicutaneous immunotherapy (EPIT), an device capable of efficiently delivering the allergen into the skin is indispensable.
In the present study, we acquired a proof-of-concept for the establishment of EPIT using allergen-containing hydrogel patch (HG). We also demonstrated our EPIT system was safe and effective in children with severe milk allergy.

Free Research Field

免疫学、ワクチン学