Identification and clinical application of diagnostic and therapeutic marker of esophageal and gastric cancer targeting cancer stem cell

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04713
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: YASUI WATARU 広島大学, 医歯薬保健学研究科(医), 教授 (40191118)
• Co-Investigator(Renkei-kenkyūsha): OUE NAOHIDE 広島大学, 大学院医歯薬保健学研究科, 准教授 (60346484) ; KUNIYASU HIROKI 奈良県立医科大学, 医学部, 教授 (00253055)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 食道癌 / 胃癌 / 癌幹細胞 / CAST法 / 新規診断・治療標的

Outline of Final Research Achievements

As candidate diagnostic and therapeutic targets of esophageal and gastric cancers associated with spheroid-forming cancer stem cells, kinesin family (KIFC1, KIF11, KIF23), IQGAP3, DSG1 were identified. BST2 and MCOLN3, identified from 5-FU-resistant gastric cancer cells, were found to regulate chemosensitivity. These findings will contribute to the application to the diagnosis and treatment for therapy-resistant cancer stem cells.

Free Research Field

医歯薬学