Insight into mechanisims undelying Primary aldosteronism

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04852
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Gunma University
• Principal Investigator: Masanobu Yamada 群馬大学, 大学院医学系研究科, 教授 (90261833)
• Co-Investigator(Kenkyū-buntansha): 小澤 厚志 群馬大学, 大学院医学系研究科, 助教 (10573496) ; 堀口 和彦 群馬大学, 医学部附属病院, 医員 (10737943) ; 佐藤 哲郎 群馬大学, 医学部附属病院, 講師 (40302484) ; 桑原 正靖 群馬大学, 大学院理工学府, 准教授 (40334130) ; 石井 角保 群馬大学, 医学部附属病院, 助教 (60638112) ; 中島 康代 群馬大学, 医学部附属病院, 助教 (70707017) ; 渋沢 信行 群馬大学, 医学部附属病院, 助教 (90396622)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 原発性アルドステロン症 / 高血圧症 / 腫瘍発生

Outline of Final Research Achievements

Hypertension is the greatest cause of arteriosclerotic disease that accounts for about 1/3 of the cause of death in Japan. In recent years, it was revealed that about 10% of it is caused by primary aldosteronism (PA). In this study, we made model mice and cell lines introducing somatic mutations of aldosterone producing adenomas, and also performed a proteome analysis of serum before and after the surgery to investigate mechanisms underlying tumorigenesis of PA and cause of high occurrence of cardiovascular disorders in patients with PA.

Free Research Field

内分泌代謝学