2017 Fiscal Year Final Research Report
B cell and autoantibody in the pathogenesis of dermatomyositis
| Project/Area Number |
15H04885
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
OKIYAMA Naoko 筑波大学, 医学医療系, 講師
MATSUSHITA Takashi 金沢大学, 医薬保健研究域, 講師
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 免疫 |
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| Outline of Final Research Achievements |
By immunizing mice with human TIF1γ protein together with complete adjuvant, it was confirmed that anti-TIF1γ antibody was produced in C56BL/6 wild type mice, and antigen-specific T cells were also induced. It was histologically confirmed that myositis is induced in wild type mice. No symptoms such as muscle weakness or dermatitis appeared. It was confirmed that myositis was induced in naive mice by transfer of T cells from mice in which myositis was induced. By contrast, myositis was not caused by transfer of purified IgG from immunized mice. However, in mice deficient in CD19, myositis was not induced, suggesting that B cells also had some role.
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| Free Research Field |
皮膚科学
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