2017 Fiscal Year Final Research Report
Development of novel imaging biomarker using highly-sensitive tau PET probes
| Project/Area Number |
15H04900
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku Medical and Pharmaceutical University (2016-2017)
Tohoku University (2015) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Katsutoshi 東北医科薬科大学, 医学部, 教授 (30241631)
TASHIRO Manabu 東北大学, サイクロトロンRIセンター, 教授 (00333477)
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| Research Collaborator |
HARADA Ryuichi
FURUMOTO Shozo
KUDO Yukitsuka
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アルツハイマー病 / 進行性核上性麻痺 / PET / タウ / モノアミン酸化酵素 / グリオーシス |
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| Outline of Final Research Achievements |
Longitudinal 18F-THK5351 PET studies were conducted in patients with Alzheimer's disease. In patients with Alzheimer's disease, significant radiotracer retention was observed in the frequent areas of neurofibrillary tangle formation. The amount and spatial extension of radiotracer binding was closely associated with clinical severity and progression of dementia. Significant THK5351 retention was also observed in the globus pallidus and midbrain of patients with progressive supranuclear palsy. THK5351 retention in the basal ganglia was additionally observed in healthy control subjects and associated with radiotracer binding to monoamine oxidase B. Imaging-autopsy correlation analysis revealed that THK5351 retention was associated with both paired helical filament of tau and astrogliosis in the brain.
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| Free Research Field |
薬理学、核医学
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