Elucidation of the mechanism of urinary stone formation in metabolic syndrome and its application to molecular target treatment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04976
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Okada Atsushi 名古屋市立大学, 大学院医学研究科, 准教授 (70444966)
• Co-Investigator(Kenkyū-buntansha): 安井 孝周 名古屋市立大学, 大学院医学研究科, 教授 (40326153) ; 安藤 亮介 名古屋市立大学, 医学(系)研究科(研究院), その他 (30381867) ; 田口 和己 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00595184) ; 戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733) ; 郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 尿路結石 / メタボリックシンドローム / オステオポンチン / マクロファージ / 白色脂肪細胞 / ベージュ細胞 / 抗オステオポンチン抗体 / β3作動薬

Outline of Final Research Achievements

We have reported that urolithiasis is a condition of Metabolic Syndrome (MetS). In this study, the following study was conducted to elucidate the relation between calculus formation stone formation stone matrix osteopontin (OPN) in MetS environment.
[1] Establishment of a co-culture system of adipocytes, macrophages and tubule cells, the attachment ability of calcium oxalate monohydrate crystals was most enhanced in the co-existence environment of three cells rather than tubule cells alone. [2] β3 agonist inducing beige cells with anti-MetS action was administered, and stone formation was significantly suppressed. [3] Urinary stones and arteriosclerosis were significantly suppressed by administering anti-OPN antibody to MetS model mice.

Free Research Field

尿路結石