Pre-clinical proof of concept trials for auditory hair cell regeneration by using hiPSC technology and marmoset model

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04991
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: Fujioka Masato 慶應義塾大学, 医学部(信濃町), 講師 (70398626)
• Co-Investigator(Kenkyū-buntansha): 小川 郁 慶應義塾大学, 医学部, 教授 (00169179) ; 岡野 ジェイムス洋尚 東京慈恵会医科大学, 医学部, 教授 (90338020) ; 水足 邦雄 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 耳鼻咽喉科科, 講師 (40338140) ; 原田 竜彦 国際医療福祉大学, 大学病院, 教授 (60238186) ; 細谷 誠 慶應義塾大学, 医学部(信濃町), 助教 (30645445)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 内耳再生 / 耳科学 / 聴覚医学 / hiPS細胞 / 橋渡し研究

Outline of Final Research Achievements

We previously reported auditory hair cell regeneration with a hearing improvement in mouse (Neuron, 2013). Towards translation to the clinical trials, we selected better compounds by using otic progenitor cells derived from human iPS cells. We also examined the effect of above mentioned regenerative therapy in a non-human primate common marmoset.

Free Research Field

耳科学