Comprehensive pathological analysis of detached retina and development of new treatment for the cell protection

2017 Fiscal Year Annual Research Report

• Project/Area Number: 15H04994
• Research Institution: Nagoya University
• Principal Investigator: 寺崎 浩子 名古屋大学, 医学系研究科, 教授 (40207478)
• Co-Investigator(Kenkyū-buntansha): 伊藤 逸毅 名古屋大学, 医学系研究科, 准教授 (10313991) ; 兼子 裕規 名古屋大学, 医学部附属病院, 病院講師 (20647458) ; 上野 真治 名古屋大学, 医学部附属病院, 講師 (80528670) ; 岩瀬 剛 名古屋大学, 医学部附属病院, 講師 (80642339)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 剥離網膜 / 網膜電図 / 光干渉断層計 / 補償光学 / 眼循環 / インターロイキン１β / microRNA / カペリオン１

Outline of Annual Research Achievements

剥離網膜の微細構造と網膜機能の障害,ならびにその回復について，網膜電図（ERG),光干渉断層計（OCT),補償光学眼底撮影（AO）,laser speckle flowgraphy(LSFG)を用いて検討した．結果，黄斑剥離を伴う裂孔原性網膜剥離の術後6か月では，黄斑部局所ERG 15度のa波振幅は対側眼の66％，b波振幅は74％であった.OCTでは，黄斑剥離を伴う裂孔原性網膜剥離術後の中心窩の視細胞の再生を1年にわたって観察し，経時的な視力の回復の程度と視細胞の外節の伸長との間には有意な相関がみられた．AOを用いて黄斑部局所ERGと錐体細胞密度との関係を初めて調べた．その結果，中心窩から2度の錐体細胞密度は，a波，b波，OPsの振幅と有意に相関した．網膜剥離手術後では，錐体細胞密度は平均6か月から12か月まで有意に回復していたが，12か月時の錐体細胞密度は僚眼の錐体細胞密度の約60%であった。次にLSFGにより，網膜剥離に対し硝子体手術を行った症例では術前に視神経乳頭上の網膜血流が減少しており，術後に回復することが分かった．さらなる視機能改善を目指して，顕微鏡に搭載された術中OCTにより網膜復位の状態を観察し，中心窩下にはピラミッド型に網膜下液が残存することを見出した.23 Gまたは25 G術中ファイバーOCTの開発を行い動物ならびに症例提示を行った．さらなる病態解明と治療開発を目指して，分子生物学的アプローチにていくつかの知見を得た。裂孔原性網膜剥離眼の網膜下液には高い濃度でIL-1βが存在することを確認した．網膜剥離眼の硝子体で特異的に発現するhsa-miR-148a-3pが，RPEのEMTに関与していることが示唆された．さらに，増殖膜中のカベオリン1はRPEのEMTに抑制的な役割を有し，PVR発症に抑制的に作用していると考えられた。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Multiple sub-internal limiting membrane hemorrhages with double ring sign in eyes with Valsalva Retinopathy. (2018)
  • Author(s): Iwase T, Ra E, Ito Y, Terasaki H.
  • Journal Title: Retina. Volume: 38 Pages: e1-e2
  • DOI: 10.1097/IAE.0000000000001935.
  • Peer Reviewed / Open Access
• [Journal Article] Case of cone dystrophy with normal fundus appearance associated with biallelicPOC1Bvariants. (2018)
  • Author(s): Kominami A, Ueno S, Kominami T, Nakanishi A, Ito Y, Fujinami K, Tsunoda K, Hayashi T, Kikuchi S, Kameya S, Iwata T, Terasaki H.
  • Journal Title: Ophthalmic Genet. Volume: 39 Pages: 255-262
  • DOI: 10.1080/13816810.2017.1408846.
  • Peer Reviewed / Open Access
• [Journal Article] Quantification of Macular Microvascular Changes in Patients With Retinitis Pigmentosa Using Optical Coherence Tomography Angiography. (2018)
  • Author(s): Inooka D, Ueno S, Kominami T, Sayo A, Okado S, Ito Y, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 59 Pages: 433-438
  • DOI: 10.1167/iovs.17-23202.
  • Peer Reviewed / Open Access
• [Journal Article] Changes in refractivecharacteristics in Japanese children with Down syndrome. (2018)
  • Author(s): Horio J, Kaneko H, Takayama K, Tuzuki K, Kakihara H, Iwami M, Kawase Y, Tsunekawa T, Yamaguchi N, Nonobe N, Terasaki H.
  • Journal Title: Jpn J Ophthalmol. Volume: 62 Pages: 231-236
  • DOI: 10.1007/s10384-018-0565-x.
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety outcomes of intravitral aflibercept focusing on patients with diabetic macular edema from Japan. (2018)
  • Author(s): Terasaki H, Shiraki K, Ohji M, Metzig C, Schmelter T, Zeitz O, Sowade O,Kobayashi M, Vitti R, Berliner A, Shiraga F
  • Journal Title: Retina. Volume: 0 Pages: 0
  • DOI: 10.1097/IAE.0000000000002100.
• [Journal Article] Changes in refractive characteristics in Japanese children with Down syndrome. (2018)
  • Author(s): Horio J, Kaneko H, Takayama K, Tuzuki K, Kakihara H, Iwami M, Kawase Y, Tsunekawa T, Yamaguchi N, Nonobe N, Terasaki H
  • Journal Title: Jpn J Ophthalmol Volume: 62 Pages: 231-236
  • DOI: 10.1007/s10384-018-0565-x.
• [Journal Article] Macular displacement after vitrectomy in eyes with idiopathic macular hole determined by optical coherence tomography angiography. (2018)
  • Author(s): Akahori T, Iwase T, Yamamoto K, Ra E, Kawano K, Ito Y, Terasaki H.
  • Journal Title: Am J Ophthalmol Volume: 0 Pages: 0
  • DOI: 10.1016/j.ajo.2018.02.021.
• [Journal Article] cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. (2018)
  • Author(s): Terasaki H(他37名）
  • Journal Title: Nat Med. Volume: 24 Pages: 50-61
  • DOI: 10.1038/nm.4450
• [Journal Article] Efficacy and safety ourcomes of intravitreal aflibercept focusing on patients with diabetic macular edema from Japan (2018)
  • Author(s): Terasaki H, Shiraki K, Ohji M, Metzig C, Schmelter T, Zeitz O, Sowade O, Kobayashi M, Vitti R, Berliner A, Shiraga F.
  • Journal Title: Retina Volume: 0 Pages: 0
  • DOI: 10.1097/IAE.0000000000002100
• [Journal Article] Comparison of indocyanine green angiography and optical coherence tomographic angiography in polypoidal choroidal vasculopathy. (2017)
  • Author(s): Takayama K, Ito Y, Kaneko H, Kataoka K, Sugita T, Maruko R, Hattori K, Ra E, Haga F, Terasaki H.
  • Journal Title: Eye (Lond). Volume: 31 Pages: 45-52
  • DOI: 10.1038/eye.2016.232.
  • Peer Reviewed / Open Access
• [Journal Article] Short-term focal macular electroretinogram of eyes treated by aflibercept & photodynamic therapy for polypoidal choroidal vasculopathy. (2017)
  • Author(s): Takayama K, Kaneko H, Kataoka K, Ueno S, Chang-Hua P, Ito Y, Terasaki H.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 255 Pages: 449-455
  • DOI: 10.1007/s00417-016-3468-x.
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of short-term outcomes of intravitreal aflibercept injections for age-related macular degeneration using focal macular electroretinography. (2017)
  • Author(s): Takayama K, Kaneko H, Ueno S, Maruko R, Piao CH, Yasuda S, Kawano K, Ito Y, Terasaki H
  • Journal Title: Retina. Volume: 37 Pages: 553-560
  • DOI: 10.1097/IAE.0000000000001225.
  • Peer Reviewed / Open Access
• [Journal Article] Clinical practice pattern in management of diabetic macular edema in Japan: survey results of Japanese retinal specialists. (2017)
  • Author(s): Ogura Y, Shiraga F, Terasaki H, Ohji M, Ishida S, Sakamoto T, Hirakata A, Ishibashi T.
  • Journal Title: Jpn J Ophthalmol. Volume: 61 Pages: 43-50
  • DOI: 10.1007/s10384-016-0481-x.
  • Peer Reviewed / Open Access
• [Journal Article] In vivo imaging of a cone mosaic in a patient with achromatopsia associated with a GNAT2 variant. (2017)
  • Author(s): Ueno S, Nakanishi A, Kominami T, Ito Y, Hayashi T, Yoshitake K, Kawamura Y, Tsunoda K, Iwata T, Terasaki H.
  • Journal Title: Jpn J Ophthalmol Volume: 67 Pages: 92-98
  • DOI: 10.1007/s10384-016-0484-7.
  • Peer Reviewed / Open Access
• [Journal Article] Canges of outer retinal thickness with increasing age in normal fellow eyes of patients with unilateral age-related macular degenetation. (2017)
  • Author(s): Kenmochi J, Ito Y, Terasaki H.
  • Journal Title: Retina. Volume: 37 Pages: 47-52
  • DOI: 10.10197/Iae.0000000000001131
  • Peer Reviewed / Open Access
• [Journal Article] Better Visual Outcome by Intraocular Lens Ejection in Geriatric Patients with Ruptured Ocular Injuries. (2017)
  • Author(s): Kaneko H(他7名1番目), Ito Y, (他7名9番目),Ueno S, Nonobe N, Kataoka K, , Iwase T(他7名14番目), Terasaki H(他7名15番目).
  • Journal Title: PLoS One. Volume: 12 Pages: e0170094
  • DOI: 10.1371/journal.pone.0170094.
  • Peer Reviewed / Open Access
• [Journal Article] Role of caveolin-1 for blocking the epithelial-mesenchymal transition in proliferative vitreoretinopathy. (2017)
  • Author(s): Nagasaka Y, Kaneko H, Ye F, Kachi S, Asami T, Kato S, Takayama K, Hwang SJ, Kataoka K, Shimizu H, Iwase T, Funahashi Y, Higuchi A, Senga T, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Pages: 221-229
  • DOI: 10.1167/iovs.16-20513.
  • Peer Reviewed / Open Access
• [Journal Article] One-Year Outcomes of 1 + pro re nata versus 3 + pro re nata intravitreal aflibercept injection for neovascular age-related macular degeneration. (2017)
  • Author(s): Takayama K, Kaneko H, Sugita T, Maruko R, Hattori K, Ra E, Kawano K, Kataoka K, Ito Y, Terasaki H.
  • Journal Title: Ophthalmologica. Volume: 237 Pages: 105-110
  • DOI: 10.1159/000461785.
  • Peer Reviewed / Open Access
• [Journal Article] Changes in retinal microcirculation after intravitreal ranibizumab injection in eyes with macular edema secondary to branch retinal vein occlusion. (2017)
  • Author(s): Fukami M, Iwase T, Yamamoto K, Kaneko H, Yasuda S, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Pages: 1246-1255
  • DOI: 10.1167/iovs.16-21115.
  • Peer Reviewed / Open Access
• [Journal Article] Nutritional supplementation inhibits the increase in serum malondialdehyde in patients with wet age-related macular degeneration. (2017)
  • Author(s): Matsuura T, Takayama K, Kaneko H, Ye F, Fukukita H, Tsunekawa T, Kataoka K, Hwang SJ, Nagasaka Y, Ito Y, Terasaki H.
  • Journal Title: Oxid Med Cell Longev. Volume: 0 Pages: 9548767
  • DOI: 10.1155/2017/9548767.
  • Peer Reviewed / Open Access
• [Journal Article] Contributions of second- and third-order retinal neurons to cone electroretinograms after loss of rod function in rhodopsin P347L transgenic rabbits. (2017)
  • Author(s): Kominami T, Ueno S, Okado S, Nakanishi A, Kondo M, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Pages: 1417-1424
  • DOI: 10.1167/iovs.16-20344.
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between miR-148 expression in vitreous and severity of rhegmatogenous retinal detachment (2017)
  • Author(s): Tsunekawa T, Kaneko H, Takayama K, Hwang SJ, Oishi A, Nagasaka Y, Ye F, Iwase T, Nonobe N, Ueno S, Ito Y, Yasuda S, Matsuura T, Shimizu H, Suzumura A, Kataoka K, Terasaki H.
  • Journal Title: Biomed Res Int. Volume: 0 Pages: 3427319
  • DOI: 10.1155/2017/3427319.
  • Peer Reviewed / Open Access
• [Journal Article] Bilateral lacrimal caruncle lesions. (2017)
  • Author(s): Okumura Y, Takai Y, Yasuda S, Terasaki H. Bilateral lacrimal caruncle lesions.
  • Journal Title: Nagoya J Med Sci. Volume: 79 Pages: 103-108
  • DOI: 10.18999/nagjms.79.1.85
  • Peer Reviewed / Open Access
• [Journal Article] High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. (2017)
  • Author(s): Takayama K, Ito Y, Kaneko H, Kataoka K, Ra E, Terasaki H
  • Journal Title: Nagoya J Med Sci. 2017 Volume: 79 Pages: 103-108
  • DOI: 10.1111/aos.13244.
  • Peer Reviewed / Open Access
• [Journal Article] Change in choroidal blood flow and choroidal morphology due to segmental scleral buckling in eyes with rhegmatogenous retinal detachment. (2017)
  • Author(s): Iwase T, Kobayashi M, Yamamoto K, Yanagida K, Ra E, Terasaki H.
  • Journal Title: Sci Rep. Volume: 20 Pages: 5997
  • DOI: 10.1038/s41598-017-05126-1.
  • Peer Reviewed / Open Access
• [Journal Article] Biological Involvement of MicroRNAs in Proliferative Vitreoretinopathy. (2017)
  • Author(s): Kaneko H, Terasaki H.
  • Journal Title: Transl Vis Sci Technol. Volume: 6 Pages: 5
  • DOI: 10.1167/tvst.6.4.5.
  • Peer Reviewed / Open Access
• [Journal Article] Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases (2017)
  • Author(s): Kaneko H, Takayama K, Asami T, Ito Y, Tsunekawa T, Iwase T, Funahashi Y, Ueno S, Nonobe N, Yasuda S, Suzumura A, Shimizu H, Kimoto R, Hwang SJ, Terasaki H.
  • Journal Title: Sci Rep Volume: 7 Pages: 2640
  • DOI: 10.1038/s41598-017-03124-x
  • Peer Reviewed / Open Access
• [Journal Article] Long-term results after limited macular translocation surgery for wet age-related macular degeneration. (2017)
  • Author(s): Oshima H, Iwase T, Ishikawa K, Yamamoto K, Terasaki H.
  • Journal Title: PLoS One. Volume: 12 Pages: e0177241
  • DOI: 10.1371/journal.pone.0177241
  • Peer Reviewed / Open Access
• [Journal Article] Better prognosis for eyes wish preserve foveal depression after intravitreal ranibizumab injection for macular edema secondary to central retinal vein occlusion. (2017)
  • Author(s): Kitagawa S, Yasuda S, Ito Y, Ueno S, Iwase T, Terasaki H.
  • Journal Title: Retina. Volume: 0 Pages: 0
  • DOI: 10.1097/IAE.0000000000001707
• [Journal Article] Comparison between 1-year outcomes of aflibercept with and without photodynamic therapy for polypoidal choroidal vasculopathy: Retrospective observation study. (2017)
  • Author(s): Takayama K, Kaneko H, Kataoka K, Hattori K, Ra E, Tsunekawa T, Fukukita H, Haga F, Ito Y, Terasaki H.
  • Journal Title: PLoS One. Volume: 12 Pages: e0176100
  • DOI: 10.1371/journal.pone.0176100
  • Peer Reviewed / Open Access
• [Journal Article] Differences in ocular findings in two siblings: one with complete and other with incomplete achromatopsia. (2017)
  • Author(s): Ueno S, Nakanishi A, Sayo A, Kominami T, Ito Y, Hayashi T, Tsunoda K, Iwata T, Terasaki H.
  • Journal Title: Doc Ophthalmol. Volume: 134 Pages: 141-147
  • DOI: 10.1007/s10633-017-9577-y.
  • Peer Reviewed / Open Access
• [Journal Article] Regeneration of Photoreceptor Outer Segments After Scleral Buckling Surgery for Rhegmatogenous Retinal Detachment. (2017)
  • Author(s): Ra E, Ito Y, Kawano K, Iwase T, Kaneko H, Ueno S, Yasuda S, Kataoka K,Terasaki H.
  • Journal Title: Am J Ophthalmol. Volume: 177 Pages: 17-26
  • DOI: 10.1016/j.ajo.2017.01.032.
  • Peer Reviewed / Open Access
• [Journal Article] Half-dosephotodynamic therapy for chronic central serous chorioretinopathy evaluated byfocal macular electroretinograms. (2017)
  • Author(s): Oiwa K, Kataoka K, Maruko R, Ueno S, Ito Y, Terasaki H.
  • Journal Title: Jpn J Ophthalmol. Volume: 61 Pages: 260-266
  • DOI: 10.1007/s10384-017-0498-9.
  • Peer Reviewed / Open Access
• [Journal Article] Associations between outer retinal structures and focal macular electroretinograms in patients with retinitis pigmentosa. (2017)
  • Author(s): Kominami T, Ueno S, Kominami A, Nakanishi A, Yasuda S, Piao CH, Okado S, Terasaki H.
  • Journal Title: Invest ophthalmol Vis Sci. Volume: 58 Pages: 5122-5128
  • DOI: 10.1167/iovs.17-22040.
  • Peer Reviewed / Open Access
• [Journal Article] Changes in choroidal blood flow and morphology in response to increase in intraocular rressure. (2017)
  • Author(s): Akahori T, Iwase T, Yamamoto K, Ra E, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Pages: 5076-5085
  • DOI: 10.1167/iovs.17-21745.
  • Peer Reviewed / Open Access
• [Journal Article] Perioperative factors that are significantly correlated with final visual acuity in eyes after successful rhegmatogenous retinal detachment surgery. (2017)
  • Author(s): Kobayashi M, Iwase T, Yamamoto K, Ra E, Murotani K, Terasaki H.
  • Journal Title: PLoS One. Volume: 12 Pages: e0184783
  • DOI: 10.1371/journal.pone.0184783.
  • Peer Reviewed / Open Access
• [Journal Article] Increased retinal thinning after combination of internal limiting membrane peeling and silicone oil endotamponade in proliferative diabetic retinopathy. (2017)
  • Author(s): Kaneko H, Matsuura T, Takayama K, Ito Y, Iwase T, Ueno S, Nonobe N, Yasuda S, Kataoka K, Terasaki H.
  • Journal Title: Ophthalmologica. Volume: 238 Pages: 226-235
  • DOI: 10.1159/000479482.
  • Peer Reviewed / Open Access
• [Journal Article] Changes of outer retinal thickiness with increasing agein normal eyes and in normal fellow eyes of patients with unilateral age-related macular degeneration. (2017)
  • Author(s): Kenmochi J, Ito Y, Terasaki H.
  • Journal Title: Retina. Volume: 37 Pages: 47-52
  • DOI: 10.1097/IAE.0000000000001131.
  • Peer Reviewed / Open Access
• [Journal Article] Temporal Properties of Flicker ERGs in Rabbit Model of Retinitis Pigmentosa. (2017)
  • Author(s): Okado S, Ueno S, Kominami T, Nakanishi A, Inooka D, Sayo A, Kondo M, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Pages: 5518-5525
  • DOI: 10.1167/iovs.17-22332.
• [Journal Article] Diurnal variation of pulse waveform parameters determined by laser speckle flowgraphy on the optic nerve head in healthy subjects. (2017)
  • Author(s): Fukami M, Iwase T, Yamamoto K, Ra E, Murotani K, Terasaki H.
  • Journal Title: Medicine (Baltimore). Volume: 96 Pages: e8312
  • DOI: 10.1097/MD.0000000000008312.
  • Peer Reviewed / Open Access
• [Journal Article] Predictive factors ofsurgical outcomes in vitrectomy for myopic traction maculopathy. (2017)
  • Author(s): Hattori K, Kataoka K, Takeuchi J, Ito Y, Terasaki H.
  • Journal Title: Retina Volume: 0 Pages: 0
  • DOI: 10.1097/IAE.0000000000001927.
• [Journal Article] Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa (2017)
  • Author(s): Sayo A, Ueno S, Kominami T, Nishida K, Inooka D, Nakanishi A, Yasuda S, Okado S, Takahashi K, Matsui S, Terasaki H.
  • Journal Title: Sci Rep. Volume: 7 Pages: 16383
  • Peer Reviewed / Open Access
• [Journal Article] Optical coherence tomography angiography of the foveal avascular zone in children with a history of treatment-requring retinopathy of prematurity. (2017)
  • Author(s): Nonobe N, Kaneko H, Ito Y, Takayama K, Kataoka K, Tsunekawa T, Matsuura T, Suzumura A, Shimizu H, Terasaki H.
  • Journal Title: Retina. Volume: 0 Pages: 0
  • DOI: 10.1097/IAE.0000000000001937.
• [Journal Article] Case of cone dystrophy with normal fundus appearance associated with biallelic POC1B variants. (2017)
  • Author(s): Kominami A, Ueno S, Kominami T, Nakanishi A, Ito Y, Fujinami K, Tsunoda K, Hayashi T, Kikuchi S, Kameya S, Iwata T, Terasaki H.
  • Journal Title: Ophthalmic Genet. Volume: 0 Pages: 1-8
  • DOI: 10.1080/13816810.2017.1408846.
  • Peer Reviewed / Open Access
• [Journal Article] Migration of segmental arteriolar fluorescein staining peripherally in eye with idiopathic recurrent branch retinal arterial occlusion. (2017)
  • Author(s): Kawano K, Ito Y, Haga F, Tsunekawa T, Terasaki H.
  • Journal Title: Am J Ophthalmol Case Rep. Volume: 7 Pages: 80-82
  • DOI: 10.1016/j.ajoc.2017.06.009
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Immunoglobulin G4-associated Anterior Uveitis and Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome. (2017)
  • Author(s): Takayama K, Kaneko H, Terasaki H.
  • Journal Title: Ocul Immunol Inflamm. Volume: 25 Pages: 693-694
  • DOI: 10.3109/09273948.2016.1161056.
  • Peer Reviewed / Open Access
• [Journal Article] 網膜機能障害解析の多角的アプローチ－網膜剥離を中心に（総説） (2017)
  • Author(s): 寺崎浩子、他
  • Journal Title: 日本眼科学会雑誌 Volume: 121 Pages: 185-231
  • Peer Reviewed
• [Journal Article] カレント・トピックス 光干渉断層計血管撮影（解説） (2017)
  • Author(s): 寺崎浩子
  • Journal Title: 日本医師会雑誌 Volume: 145 Pages: 2140
  • Peer Reviewed
• [Journal Article] 光干渉断層血流造影で撮影したLeber遺伝性視神経症の2例4眼 (2017)
  • Author(s): 高山 圭, 兼子 裕規, 野々部 典枝, 羅 英明, 恒川 太一, 伊藤 逸毅, 寺崎 浩子
  • Journal Title: 神経眼科 Volume: 3 Pages: 311-316
• [Journal Article] 網膜機能障害解析の多角的アプローチ 網膜剥離を中心に (2017)
  • Author(s): 寺崎 浩子, 伊藤 逸毅, 岩瀬 剛, 兼子 裕規, 片岡 恵子, 杉田 糾, 丸子 留佳, 浅見 哲, 安田 俊介, 高山 圭, 大岩 和博, 川野 健一, 白井 博志, 羅 英明, 山本 健太郎, 中西 絢美, 小南 太郎, 古林 充里, 小南 梓, 長坂 洋介, 柳田 紘生, Vavvas Demetrios G., Miller Joan W.
  • Journal Title: 日本眼科学会雑誌 Volume: 121 Pages: 185-231
• [Presentation] OCT imaging in the nursery :a new perspective on infant eye and brain development and disease (2018)
  • Author(s): 寺崎浩子
  • Organizer: 第32回日本小児眼科学会
• [Presentation] Analysis of Choroidal neovascularization (by OCTA) (2018)
  • Author(s): Terasaki H
  • Organizer: The 4th Annual Meeting of Kwak Retinal Imaging Symposium (KRIS-APIS)
• [Presentation] Macula vascular density in diabetic retinopathy (Measured by OCT Angiography) (2018)
  • Author(s): Terasaki H
  • Organizer: APAO2018
• [Presentation] New Imaging Tools (Including OCT-A) in DR (2018)
  • Author(s): Terasaki H
  • Organizer: APAO 2018
• [Presentation] Intraoperative OCT (2018)
  • Author(s): Terasaki H
  • Organizer: APAO 2018
• [Presentation] 眼光学と視機能－各領域におけるUpdate (2017)
  • Author(s): 寺崎浩子、島崎潤（他学）
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 次世代シークエンサーによる加齢黄斑変性症感受性多型の同定 (2017)
  • Author(s): 寺崎浩子、安間哲宏（他23名）
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 増殖糖尿病網膜症への内境界膜剥離とシリコーンオイル挿入による黄斑部網膜厚への影響 (2017)
  • Author(s): 寺崎浩子、伊藤逸毅、岩瀬剛、上野真治、兼子裕規（他5名）
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 星状硝子体症合併症加齢黄斑変性症への抗血管内皮細胞増殖因子硝子体投与の効果 (2017)
  • Author(s): 寺崎浩子、伊藤逸毅、片岡恵子（他6名）
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 網膜硝子体：出血下の網膜構造評価に波長掃引型干渉断層計が有用であった一例 (2017)
  • Author(s): 寺崎浩子、伊藤逸毅、兼子裕規、片岡恵子（他4名）
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 網膜剥離眼硝子体中のhsa-miR148-3p 発現量とサイトカイン発現量 (2017)
  • Author(s): 寺崎浩子、兼子裕規（他2名）
  • Organizer: 第121回日本眼科学会総会
• [Presentation] OCT angiographyで網膜血管の異常が検出されたAlport症候群の一例 (2017)
  • Author(s): 寺崎浩子、伊藤逸毅、上野真治、片岡恵子、武内潤
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 網膜色素変性におけるHumphrey10-2視野の長期変化 (2017)
  • Author(s): 寺崎浩子、上野真治（他5名）
  • Organizer: 第121回日本眼科学会総会
• [Presentation] POCｌB変異の錐体ジストロフィの1症例 (2017)
  • Author(s): 寺崎浩子、伊藤逸毅、上野真治（他7名）
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 中心窩陥凹の残存する網膜中心静脈閉塞眼に対する高血管皮増殖因子療法後の予後 (2017)
  • Author(s): 寺崎浩子、伊藤逸毅、岩瀬剛、上野真治、安田俊介、北川周太
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 網膜復立術の基本と極意 (2017)
  • Author(s): 寺崎浩子、兼子裕規、竹内忍(他院）
  • Organizer: 日本臨床眼科学会
• [Presentation] Valsalva網膜症の一例 (2017)
  • Author(s): 寺崎浩子、伊藤逸毅、岩瀬剛(他2名）
  • Organizer: 日本臨床眼科学会
• [Presentation] 近視性牽引黄班症の手術の予後 (2017)
  • Author(s): 寺崎浩子、片岡恵子(他2名）
  • Organizer: 日本臨床眼科学会
• [Presentation] シリコーンオイル下液の分析 (2017)
  • Author(s): 寺崎浩子、兼子裕規（他5名）
  • Organizer: 日本臨床眼科学会
• [Presentation] 網膜動静脈交叉部の静脈狭窄率 (2017)
  • Author(s): 寺崎浩子、岩瀬剛(他3名）
  • Organizer: 日本臨床眼科学会
• [Presentation] Rebound of Choroidal Neovascularization Against Aflibercept Assessed by OCT Angiography(Academic display) (2017)
  • Author(s): Terasaki H, Ito Y, Kataoka K, Takeuchi J
  • Organizer: ASRS
  • Int'l Joint Research
• [Presentation] The efficacy of intravitreal anti-vascular endothelial growth factor therapy on age-related macular degeneration with asteroidhyalosis(Free Paper Session 14) (2017)
  • Author(s): Suzumura A, Takayama K, Kaneko H, Terasaki H
  • Organizer: EURETINA
  • Int'l Joint Research
• [Presentation] Cytokine profiling in the sub-silicone oil fluid after vitrectomy surgeries for refractory retinal diseases. (Free papen session) (2017)
  • Author(s): Kaneko H, Takayama K,Tsunekawa T, Iwase T, Terasaki H
  • Organizer: EURETINA
  • Int'l Joint Research
• [Presentation] Subfoveal choroidal thickness change after pars plan vitrectomy in eyes (2017)
  • Author(s): Iwase T, Ra E, Yamamoto K, Kobayashi M, Terasaki H
  • Organizer: EURETINA
  • Int'l Joint Research
• [Presentation] Multiple sub-internal limiting membrane hemorrhages with double ring sign in eyes with Valsalva retinopathy. (Poster Presentations) (2017)
  • Author(s): Goto k,Iwase T, Ra E, Ito Y, Terasaki H.
  • Organizer: APAO
  • Int'l Joint Research
• [Presentation] 最近の網膜血管描線の診断と治療戦略（特別講演） (2017)
  • Author(s): 寺崎浩子
  • Organizer: 茨城県眼科医会学術講演会
• [Presentation] Retinopathy and retinal degeneration (2017)
  • Author(s): Terasaki H
  • Organizer: ARVO ASIA
  • Int'l Joint Research
• [Presentation] Intraoperative OCT (2017)
  • Author(s): Terasaki H
  • Organizer: 32nd Asia-Pacific Academy of Ophthalmology Congress
  • Int'l Joint Research
• [Presentation] When and how to treat myopic ttraction maculopathy (2017)
  • Author(s): Terasaki H
  • Organizer: AAO
  • Int'l Joint Research
• [Presentation] Visual function of retinal detachment myopic macular traction syndrome (2017)
  • Author(s): Terasaki H
  • Organizer: Duke Advanced Vitreous Surgery Course
  • Int'l Joint Research / Invited
• [Presentation] Myopic macular traction syndrome (2017)
  • Author(s): Terasaki H
  • Organizer: Duke Advanced Vitreous Surgery Course
  • Int'l Joint Research / Invited
• [Presentation] 強度近視の合併症と手術 (2017)
  • Author(s): 寺崎浩子
  • Organizer: 浜松医科大学眼科学教室 症例検討会・新入局員歓迎会
  • Invited
• [Presentation] Multiple sub-internal limiting membrane hemorrhages with double ring sign in eyes with Valsalva retinopathy(Poster Presentations) (2017)
  • Author(s): Goto k, Iwasae T, Ito Y, Terasaki H
  • Organizer: APRVRS
  • Int'l Joint Research
• [Presentation] 強度近視の眼底合併症と治療（特別講演） (2017)
  • Author(s): 寺崎浩子
  • Organizer: KPUM眼科診療スキルアップセミナー
• [Presentation] 行きたい想いが加速する 名大研究室の扉 in 河合塾 (2017)
  • Author(s): 寺崎浩子
  • Organizer: 第17回医学部「iPS細胞やプラズマなど医療の進歩が期待される眼科」iPS細胞やES細胞といった最先端の技術による眼科医療の進歩
  • Invited
• [Presentation] 糖尿病網膜症-診断・治療の新しいアプローチ（網膜血管検査を中心に）/New approaches diagnosing and treating diabetic (2017)
  • Author(s): 寺崎浩子
  • Organizer: 第21回日本糖尿病眼科学会総会（特別講演）
• [Presentation] Retinopathy and retinal degeneration (IM)(SYMPOSIUM:Chair) (2017)
  • Author(s): Terasaki H
  • Organizer: ARVO ASIA 2017
• [Presentation] Changes in choroidal blood flow and morphology in response to increase of intraocular pressure. (Postaer) (2017)
  • Author(s): Akahori T, Iwase T, Yamamoto K, Ra E, Terasaki H.
  • Organizer: ARVO2017
• [Presentation] Nutritional supplementation inhibits the increase in serum malondialdehyde in patients with wet age-related macular degeneration. (Postaer) (2017)
  • Author(s): Takayama K, Matsuura T, Kaneko H, Fukukita H, Kataoka K, Nagasaka Y, Tsunekawa T, Ito Y, Terasaki H.
  • Organizer: ARVO2017
• [Presentation] Course of visual field changes in retinitis pigmentosa patients followed by humphrey field analyzer 10-2 program. (Poster) (2017)
  • Author(s): Sayo A, Ueno S, Nakanishi A, Kominami T, Okado M, Terasaki H.
  • Organizer: ARVO2017
• [Presentation] Hyper reflective foci represent decreased fundus auto fluorescence in eyes with retinitis pigmentosa. (Poster) (2017)
  • Author(s): Nagasaka Y, Ito Y, Ueno S, Terasaki H.
  • Organizer: ARVO2017
• [Presentation] Does vitrectomy change blood flow on optic nerve head in eyes with rhegmatogenous retinal detachment? (Poster) (2017)
  • Author(s): Yanagida K, Iwase T, Kobayashi M, Yamamoto K, Ra E, Terasaki H.
  • Organizer: ARVO2017
• [Presentation] Quantitative evaluation of diabetic retinopathy using optical coherence tomography angiography. (Poster) (2017)
  • Author(s): Ito Y, Taira S, Iwase T, Nonobe N, Yasuda S, Terasaki H.
  • Organizer: ARVO2017
• [Presentation] Contributions of second and third-order retinal neurons to cone electroretinograms after loss of rod function in rhodopsin P347L transgenic rabbits (2017)
  • Author(s): Kominami T, Ueno S, Okado S, Nakanishi A, Kondo M, Terasaki H.
  • Organizer: ARVO2017
• [Presentation] Change in choroidal blood flow and morphology after segmental scleral buckling for rhegmatogenous retinal detachment? (Poster) (2017)
  • Author(s): Iwase T, Kobayashi M, Yamamoto K, Terasaki H.
  • Organizer: ARVO2017
• [Presentation] 急性帯状潜在性網膜外層症発症3年半後、反対眼に多発消失性白点症候群を発症した1例 (2017)
  • Author(s): 後藤健介、岩瀬剛、伊藤逸毅、寺崎浩子
  • Organizer: 第435回東海眼科学会