2018 Fiscal Year Final Research Report

Guided control of keratinized epithelial mucosa as a next generation periodontal soft tissue regeneration

Research Project

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Project/Area Number	15H05026
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Prosthodontics/ Dental materials science and
Research Institution	Okayama University
Principal Investigator	Maekawa Kenji 岡山大学, 医歯薬学総合研究科, 准教授 (20304313)
Co-Investigator(Kenkyū-buntansha)	大野充昭岡山大学, 医歯薬学総合研究科, 助教 (60613156) 渡辺亮京都大学, iPS細胞研究所, 特定拠点助教 (60506765) 秋山謙太郎岡山大学, 大学病院, 講師 (70423291) 窪木拓男岡山大学, 医歯薬学総合研究科, 教授 (00225195) 大島正充岡山大学, 医歯薬学総合研究科, 助教 (00548307)
Project Period (FY)	2015-04-01 – 2019-03-31
Keywords	角化歯肉 / 角化歯肉獲得法 / 基底膜 / Ⅳ型コラーゲン
Outline of Final Research Achievements	Keratinized gingiva around the tooth and dental implant is critical to maintain a healthy condition of periodontal and peri-implant tissues, however the mechanisms regulating keratinization of gingiva still remain unclear. In this study, we hypothesized that the basement membrane is a critical regulator of keratinization of the oral mucosal epithelium. From our results, we found out that the difference in keratinization of oral mucosa is associated with the composition of the basement membrane. In addition to this, the composition which highly expresses in keratinized gingiva induced human gingival epithelial cells to express keratinized marker in vitro.
Free Research Field	歯科補綴学
Academic Significance and Societal Importance of the Research Achievements	本研究において，基底膜は口腔粘膜の角化を制御する重要な因子である可能性が示唆された。つまり，角化歯肉を誘導する基底膜を人工的に作製することで、自己組織移植を回避できる可能性，さらには角化に重要な基底膜分子の発現を亢進させる薬剤を非外科的に応用することで，生物学的に非角化歯肉部位を角化歯肉に誘導できる可能性を見出すことができた。