Functional Cytokine network in the Oral Cancer Stem Cell Niche and its applicastion for diagnosis and treatment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05043
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Okamoto Tetsuji 広島大学, 医歯薬保健学研究科(歯), 教授 (00169153)
• Co-Investigator(Kenkyū-buntansha): 林堂 安貴 広島大学, 病院(歯), 講師 (70243251)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔扁平上皮癌 / 癌幹細胞 / 無血清培養 / exosome / CD133 / Side population細胞 / rBC2LCN陽性細胞 / IGF-2

Outline of Final Research Achievements

In this study, we aim to develop a novel diagnostic and therapeutic method targeting cancer stem cells in human oral squamous cell carcinoma (OSCC), and developed a specific carbohydrate structure expressed on the cell surface of undifferentiated pluripotent stem cells We analyzed the cell and molecular biological characteristics of rBC2 LCN-recognizing carbohydrate positive cell group isolated from human oral squamous-cell carcinoma-derived cell line using rBC2LCN which recognizes lectin. Furthermore, we clarified a niche mechanism controlling self-renewal ability and differentiation ability, clarify its cell / molecular biological characteristics through identification of cytokine network molecule / signal group necessary for maintaining niche function, We aim to establish diagnostic and therapeutic methods for new cancer targeting stem cells.

Free Research Field

外科系歯学