Vaccines against periodontitis using DNA ORIGAMI and imidazoquinolines

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05052
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontology
• Research Institution: Niigata University
• Principal Investigator: KOICHI TABETA 新潟大学, 医歯学系, 研究准教授 (20401763)
• Co-Investigator(Kenkyū-buntansha): 寺尾 豊 新潟大学, 医歯学系, 教授 (50397717) ; 高橋 直紀 新潟大学, 医歯学総合研究科, 特任講師 (80722842)
• Co-Investigator(Renkei-kenkyūsha): YAMAZAKI Kazuhisa 新潟大学, 医歯学系, 教授 (00182478)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯周病 / ワクチン / IgA / PCSK9 / 核酸抗原

Outline of Final Research Achievements

Although the efficacy of vaccines against an infectious disease, periodontitis, has been suggested, it has not been applied in clinical practices. In this study, we examined the possibility of development of a vaccine to prevent/treat periodontitis focusing on induction of secretory IgA production via modulation of mucosal immunity. We found that, chemokine production and follicular T cell activation were induced by imidazoquinoline derivatives which are nucleic acid antigen - like compounds, and secretory IgA production was promoted. These findings suggested the possibility of developing a periodontitis vaccine using nucleic acid antigen as an adjuvant.

Free Research Field

歯周病学