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2017 Fiscal Year Final Research Report

Neural circuit mechanisms underlying receptive field formation in higher-order visual cortical areas

Research Project

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Project/Area Number 15H05375
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Brain biometrics
Research InstitutionNagoya University

Principal Investigator

Fumitaka Osakada  名古屋大学, 創薬科学研究科, 准教授 (60455334)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywords受容野 / DREADD / hM4Di / ウイルスベクター / 視覚弁別課題 / 経路選択的 / 多光子励起イメージング / 神経薬理学
Outline of Final Research Achievements

The aim of this project is to reveal how the receptive fields of higher-order visual cortical areas (HVAs) are shaped by the thalamus. We identified synaptic input to the V1 and each HVA by injecting retrograde viruses into each visual area of mice. Neurons of the lateral geniculate nucleus (LGN) neurons project to both the V1 and various HVAs, whereas neurons of the lateral posterior nucleus (LP) project to various HVAs, but not to the V1. We imaged visual responses from axon terminals of the LP or LGN neurons expressing GCaMP6 by 2-photon microscopy. In addition, we imaged visual responses from the V1 or HVA while manipulating activity of neurons in the LP or LGN with the Designer Receptors Exclusively Activated by Designer Drug (DREADD) system. From these results, we conclude that LP neurons play a pivotal role in formation of the receptive fields of HVA neurons in mice.

Free Research Field

神経科学

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Published: 2019-03-29  

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