Artificial photosynthesis system constructed on DNA nanoreactor

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05492
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Bio-related chemistry
• Research Institution: Kyoto University
• Principal Investigator: NAKATA EIJI 京都大学, エネルギー理工学研究所, 准教授 (70467827)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: DNAナノ構造体 / DNAナノリアクター / 多段階物質変換反応 / 人工光合成システム / モジュール型アダプター / 共有結合型アダプター

Outline of Final Research Achievements

Recent development in the field of structural DNA nanotechnology has enabled the controlled self-assembly of biomacromolecules and nanomaterials. The precise and programmable base-pairing of DNA is utilized to provide fully addressable nanoarchitectures of various shapes and geometries as ideal scaffolds to position the molecules of interest with nanometer-level precision.
DNA binding-based adaptors have the potential to be an ideal protein-DNA conjugation method　to locate several kinds of proteins of interests at desired positions on the DNA scaffold with orthogonality and fast reaction kinetics to realize quantitative loading yields. By using a series of DNA binding adaptors, an enzyme cascade reaction system was constructed on the DNA scaffold.

Free Research Field

生体機能関連化学