2017 Fiscal Year Final Research Report
Understanding hypothalamic mechanisms in taste modulation with chemogenetic and optogenetic approaches
| Project/Area Number |
15H05624
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | National Institute for Physiological Sciences (2017)
The University of Tokyo (2015-2016) |
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Principal Investigator |
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| Research Collaborator |
NARUKAWA Masataka
FU Ou
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 味覚 / 視床下部 / 光遺伝学 / 化学遺伝学 |
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| Outline of Final Research Achievements |
Food is consisted of both nutrient factors and sensory factors such as taste and smell. Gustatory system plays a critical role in setting a standard to evaluate food quality. By contrast, it is known that this standard is not constant and can change depending on physiological status such as hunger. The mechanism behind this phenomenon, however, remains unclear.
To address this issue, here we manipulate hypothalamic orexigenic neurons to set artificial hunger condition in the mouse brain to analyze the mechanistic insight of hunger-induced taste modification. As a result, the activation of the orexigenic hypothalamic neurons lead to increase in sweet taste sensitivities and to decrease in aversive taste sensitivities, respectively. We revealed that novel role of hypothalamic neurons in taste modulation under hunger.
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| Free Research Field |
味覚科学、神経科学、食品科学
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