Development of a diagnostic method for nonalcoholic steatohepatitis by visualization of thymidine phosphorylase

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06001
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Higashikawa Kei 北海道大学, アイソトープ総合センター, 助教 (10756878)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: チミジンホスホリラーゼ / [123/125I]IIMU / 非アルコール性脂肪肝炎

Outline of Final Research Achievements

Our studies indicated that (1) the expression levels of TP gene and protein were significantly reduced in the liver of NASH model mice compared with that of control mice, and (2) the accumulation of [125I]IIMU was significantly decreased in the liver of of NASH model mice compared with control mice. Therefore, the nuclear medical imaging of TP by [123I]IIMU has the potential to be able to diagnose NASH.

Free Research Field

分析化学、分子イメージング、核医学