2015 Fiscal Year Final Research Report
The role of mesenchymal stem cells of cutaneous ischemia-reperfusion injury.
| Project/Area Number |
15H06079
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2016-03-31
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| Keywords | 間葉系幹細胞 / MFG-E8 / 皮膚虚血再還流障害 / 血管新生 / アポトーシス |
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| Outline of Final Research Achievements |
The secreted glycoprotein MFG-E8 has many functions, including accelerating phagocytosis of apoptotic cells by phagocytes and promoting angiogenesis. We previously reported that administration of MFG-E8 suppresses the formation of pressure ulcers induced by cutaneous ischemia-reperfusion(I/R) injury by regulating inflammation and angiogenesis. It has been reported that Mesenchymal stem cells (MSC) has the potential preventing tissue damage caused by I/R injury in several organs including brain, liver and kidney. Furthermore, we recently investigated that MSC produce large amount of MFG-E8, however, the precise mechanism of MSC-derived MFG-E8 in cutaneous I/R injury was not well known.
The aim of this study is to elucidate the mechanisms and the roles of MSC in cutaneous I/R injury involving the regulation of apoptotic cells, inflammatory reaction and angiogenesis, and the effect of MSC-derived MFG-E8 on I/R injury.
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| Free Research Field |
皮膚
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