The roll of rapid-phase parathyroid hormone secretion in chronic kidney disease-mineral and bone disorder

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06442
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: MASUDA Masashi 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (50754488)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: 慢性腎臓病

Outline of Final Research Achievements

Although plasma parathyroid hormone (PTH) and phosphorus levels were significantly increased by the administration of phosphate (40 mg) into the stomach, sympathetic and parasympathetic cannot inhibit rapid-phase PTH secretion. Next, the rapid-phase PTH secretion-induced by the administration of phosphate into the stomach was abolished by phosphonoformic acid (PFA) which suppresses the absorption of phosphate in small intestine. Although the administration of phosphate into the stomach decreased the protein expression of the type II sodium-dependent phosphate co-transporter Npt2a, capsaicin treatment which inhibits vagal afferent specific blocked the effect. Together, these results suggest that the rapid-phase PTH secretion affects signaling in the central nervous system through vagal afferent such as the phosphate sensing in small intestine, resulting in the expression of Npt2a protein in kidney.

Free Research Field

臨床栄養