Crosstalk mechanism between autophagy and apoptosis for the development of novel cancer therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 15H06550
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Osaka City University
• Principal Investigator: Doi Kenichiro 大阪市立大学, 大学院医学研究科, 病院講師 (80382050)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Keywords: オートファジー / アポトーシス / 癌治療 / 薬剤併用療法

Outline of Final Research Achievements

In recent years, elucidation of crosstalk mechanisms of autophagy and apoptosis is a global trend in the field of cancer treatment. Since cancer cells are easy to acquire drug resistance and infiltration / metastasis ability, it is essential to develop therapeutic methods that take biodiversity into consideration. It is important to develop a combination therapy to efficiently induce cancer cell death by confirming whether autophagy is also called "double-edged sword" and whether it is beneficial for cancer cell survival. In this research project we examined rat kidney cancer cell line and highly lung metastatic lines and confirmed that combinations of drugs with various inhibitors in order to suppress or induce autophagy. Pharmacological methods were mainly used to address this problem and we hope to find a novel evidence in cancer therapeutics.

Free Research Field

分子病理学、薬理学