2016 Fiscal Year Final Research Report
Start-up study for the promotion mechanisms of diabetic nephropathy by oral bacteria and the preventive dentistry
| Project/Area Number |
15H06802
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | 糖尿病 / 腎症 / Porphyromonas gingivalis / lipopolysaccharide / toll-like receptor |
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| Outline of Final Research Achievements |
We found that renal glomeruli in diabetic environment express toll-like receptors (TLR), and that diabetic mice administering periodontal pathogenic substances become nephropathy but healthy mice do not become nephropathy. TLR is an immune molecule that is primarily expressed on leukocyte, which recognizes bacteria and causes inflammation. Healthy blood vessels do not normally express. In heavy periodontitis, bacteria enter easily into the blood with brushing teeth, so it is thought that in human with both diabetes and periodontitis bacteria enter into the blood and arrive at the kidney, and nephropathy occurs by combining bacteria with TLR which is expressed in diabetic glomeruli. Therefore, it was concluded that treatment and prevention of periodontal disease in human with diabetes is very important for prevention of nephropathy.
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| Free Research Field |
矯正歯科学
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