2016 Fiscal Year Final Research Report
Pathway-specific neuronal modulation by DREADD system in primates
| Project/Area Number |
15H06872
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic / Social brain science
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Fujimoto Atsushi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 博士研究員(任常) (20756390)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Keywords | サル / DREADD / 基底核 / 意思決定 / 報酬 |
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| Outline of Final Research Achievements |
Inhibitory-DREADD (hM4Di) was surgically introduced to the bilateral rostromedial caudate (rmCD) of two monkeys. Systemic infusion of an hM4Di-selective ligand Clozapine-N-Oxide (CNO) reversibly impaired a value-based behavior of the monkeys. Neuronal recordings of the rmCD and the ventral pallidum (VP) revealed strong value coding in these areas, and the faster encoding of predicted reward value in the VP. Our results suggest that the rmCD->VP pathway could facilitate the maintenance of reward information rather than reward prediction itself.
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| Free Research Field |
認知神経科学
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