2017 Fiscal Year Annual Research Report
遺伝子発現に対するＲＮＡ分解および転写後制御の寄与
| Project/Area Number |
15J05075
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
前川 翔 東京大学, 新領域創成科学研究科, 特別研究員(DC1)
|
|---|
| Project Period (FY) |
2015-04-24 – 2018-03-31
|
| Keywords | RNA分解 / 転写制御 / ゲノム制御 / 次世代シークエンス |
|---|
| Outline of Annual Research Achievements |
The original proposal was to identify the potential role of RNA decay in mediating changes of the eventual RNA abundance.
In the last fiscal year, I was to further refine the RNA decay profile of BRIC seq, further classified the interesting set of genes that were able to be up-regulated via RNA decay, and genes that receive positive feedback and they tend to be transcription factors. I started to conduct validations to confirm that the RNA decay is the main factor that drive changes in gene expression.
In addition I have overlaid the transcription factor data to elucidate the possibility of feedback for the transcription factors.
In addition, I have compared the HIF-1 ChIP seq data to find that HIF-1 and RNA decay seems to be distinct in regulation. Alongside the lab experiments, I have been synthesizing the findings to publish a paper in an academic journal.
|
| Research Progress Status |
29年度が最終年度であるため、記入しない。
|
| Strategy for Future Research Activity |
29年度が最終年度であるため、記入しない。
|
