2017 Fiscal Year Annual Research Report

遺伝子発現に対するＲＮＡ分解および転写後制御の寄与

Research Project

Project/Area Number	15J05075
Research Institution	The University of Tokyo
Principal Investigator	前川翔東京大学, 新領域創成科学研究科, 特別研究員(DC1)
Project Period (FY)	2015-04-24 – 2018-03-31
Keywords	RNA分解 / 転写制御 / ゲノム制御 / 次世代シークエンス
Outline of Annual Research Achievements	The original proposal was to identify the potential role of RNA decay in mediating changes of the eventual RNA abundance. In the last fiscal year, I was to further refine the RNA decay profile of BRIC seq, further classified the interesting set of genes that were able to be up-regulated via RNA decay, and genes that receive positive feedback and they tend to be transcription factors. I started to conduct validations to confirm that the RNA decay is the main factor that drive changes in gene expression. In addition I have overlaid the transcription factor data to elucidate the possibility of feedback for the transcription factors. In addition, I have compared the HIF-1 ChIP seq data to find that HIF-1 and RNA decay seems to be distinct in regulation. Alongside the lab experiments, I have been synthesizing the findings to publish a paper in an academic journal.
Research Progress Status	29年度が最終年度であるため、記入しない。
Strategy for Future Research Activity	29年度が最終年度であるため、記入しない。

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