2017 Fiscal Year Final Research Report
Isolation and biological activity of marine natural compounds with bone-resorbing and bone forming properties
| Project/Area Number |
15K01803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Woo Je-Tae 中部大学, 応用生物学部・応用生物科学科 (20272693)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 破骨細胞 / 骨芽細胞 / アルカリホスファターゼ |
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| Outline of Final Research Achievements |
Two new pyrrolinone-containing lipopeptides, ypaoamides B and C, were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey’s analysis of acid hydrolysates. Ypaoamides C inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in mouse monocytic RAW264 cells. Aplysin is a known compound derived from Red Alga Laurencia nidifica collected in Okinawa. Aplysin enhanced the Alkaline Phosphatase (ALP) activity, an early osteoblast marker.
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| Free Research Field |
天然有機化合物
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