2017 Fiscal Year Final Research Report
Study of the molecular-anatomical basis common to neuromodulatory synapses
| Project/Area Number |
15K06732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アセチルコリン / ノルアドレナリン / ドーパミン / シナプス / 免疫組織化学 / 電子顕微鏡 |
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| Outline of Final Research Achievements |
We examined by immunohistochemistry the molecular composition of synaptic structures which release neuromodulators including dopamine, acetylcholine, and noradrenaline in the brain. We revealed that these synapses were composed of non-GABAergic presynaptic structures and GABAergic postsynaptic membranes. This mismatch between presynaptic and postsynaptic structures at distinct neuromodulator synapses suggests GABAergic postsynaptic molecules commonly anchor the molecular machinery to release neuromodulators to target structures.
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| Free Research Field |
神経解剖学
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