2017 Fiscal Year Final Research Report
Role of glucocorticoid conversion within the hypothalamus in metabolic regulation
| Project/Area Number |
15K09428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | グルココルチコイド / レプチン / 肥満症 / 視床下部 / 酵素 |
|---|
| Outline of Final Research Achievements |
This study was conducted to address whether glucocorticoid reactivation or inactivation by hydroxysteroid dehydrogenase type 1 and 2 within the hypothalamus affect leptin sensitivity and thus metabolic regulation of a mammal. The study result using leptin-sensitive cell line has demonstrated that glucocorticoid-mediated augmentation of leptin sensitivity is potently attenuated by the activity of hydroxysteroid dehydrogenase type 2, which converts active cortisol to inactive cortisone. The result suggests that local glucocorticoid conversion in leptin receptor-expressing cells modulate the effect of satiety-regulating hormone.
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| Free Research Field |
内分泌学
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