2017 Fiscal Year Final Research Report
Establishment of pediatric solid tumor development model using human embryonic stem cell differentiation induction system
| Project/Area Number |
15K09651
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
NODOMI Seishiro 京都大学, 医学研究科, 医員
KINEHARA Takako 京都大学, 医学研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ES細胞 / 小児固形腫瘍 / 神経堤細胞 |
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| Outline of Final Research Achievements |
CD271high neural crest cells developed during six-day differentiation induction of undifferentiated ES cells under a serum-free condition with Nodal/activin. FCM analysis of surface markers expressed during the neural crest differentiation revealed that various cell lines of pediatric solid tumors expressed CD146. Treatment with a polyclonal antibody against CD146 effectively suppressed in vivo tumor growth of malignant rhabdoid tumor and neuroblastoma cells in immunodeficient mice.
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| Free Research Field |
小児腫瘍学
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