Development of supplementary laboratory test for the differential diagnosis of depression

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09832
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Yamaguchi University
• Principal Investigator: MATSUO Koji 山口大学, 大学院医学系研究科, 准教授 (00292912)
• Co-Investigator(Kenkyū-buntansha): 山形 弘隆 山口大学, 医学部附属病院, 講師 (10549934) ; 藤田 悠介 山口大学, 大学院創成科学研究科, 准教授 (40509527) ; 松原 敏郎 山口大学, 大学教育機構, 准教授 (60526896)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経画像 / MRI / 遺伝子

Outline of Final Research Achievements

We examined biological marker for the differential diagnosis of depression and bipolar disorder using MR imaging and gene expression. We found that patients with depression showed abnormal gray matter volume and white matter integrity of frontal and temporal regions. Patients with depression demonstrated abnormal gene expressions, which were observed in depression-like mice. These findings are suggested to be potentially biomarker for the differential diagnosis of depression and bipolar disorder.

Free Research Field

精神医学