Atrial natriuretic peptide induces peroxisome proliferator

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10206
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Tohoku University
• Principal Investigator: Kawamoto Shunsuke 東北大学, 医学系研究科, 非常勤講師 (20400244)
• Co-Investigator(Kenkyū-buntansha): 齋木 佳克 東北大学, 医学系研究科, 教授 (50372298) ; 本吉 直孝 東北大学, 医学系研究科, 大学院非常勤講師 (40375093) ; 河津 聡 東北大学, 大学病院, 助教 (80633685) ; 堀井 明 東北大学, 医学系研究科, 教授 (40249983) ; 阿部 高明 東北大学, 医工学研究科, 教授 (80292209) ; 西條 芳文 東北大学, 医工学研究科, 教授 (00292277)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 心筋虚血再灌流 / ANP / PPARγ

Outline of Final Research Achievements

Atrial natriuretic peptide is a cardiac atriumderived hormone and its cardioprotective effects have recently been confirmed, but the actual mechanism
underlying these effects has not been well elucidated. In this study, we proposed that atrial natriuretic peptide achieves its effects in part via peroxisome proliferator activated receptor c, a nuclear receptor. Atrial natriuretic peptide may achieve its cardioprotective effects in part via the activation of the peroxisome proliferator activated receptor c pathway, particularly in central areas of ischemic lesions.

Free Research Field

心臓血管外科