The serum concentration of SEMA4A in eye diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10912
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyushu University (2016-2017); Fukuoka University (2015)
• Principal Investigator: Yukio Sassa 九州大学, 医学研究院, 共同研究員 (80580315)
• Co-Investigator(Kenkyū-buntansha): 奥野 龍禎 大阪大学, 医学系研究科, 助教 (00464248) ; 石橋 達朗 九州大学, 大学病院, 病院長 (30150428) ; 向野 利寛 福岡大学, 医学部, 教授 (40117106) ; 福島 修一郎 大阪大学, 基礎工学研究科, 助教 (40362644) ; 吉田 茂生 九州大学, 大学病院, 助手 (50363370) ; 安井 武史 徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (70314408)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: SEMA4A / 視神経炎 / 炎症性眼疾患

Outline of Final Research Achievements

We evaluated the serum concentrations of SEMA4A in eye diseases. The average serum concentration of SEMA4A in all patients evaluated was 3702+/-8583U/ｍl(n=248). In the optic neuritis patients, SEMA4A might be higher than other diseases(5746+/12390U/ml, n=12). SEMA4A might also be higher in patients with Vogt-Koyanagi-Harada disease.(12502+/-11202U/ml, n=5). The vitreous concentration of SEMA4A was much lower compared with the serum concentration( 232+/-95.6U/ml n=12).SEMA4A might play a role on progressing these eye diseases but might not be useful as a specific biomarker.The further study must be needed to clarify these results because of the small sample number.

Free Research Field

眼科