Development of implant and bisphosphonate-related osteonecrosis of the jaw in rats

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11166
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Nagasaki University
• Principal Investigator: KATO Hatsumi 長崎大学, 病院(歯学系), 医員 (30613608)
• Co-Investigator(Kenkyū-buntansha): 澤瀬 隆 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (80253681) ; 佐々木 宗輝 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10706336) ; 黒嶋 伸一郎 長崎大学, 病院(歯学系), 講師 (40443915)
• Co-Investigator(Renkei-kenkyūsha): ISHISAKI Akira 岩手医科大学, 歯学部, 教授 (20356439)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ビスフォスフォネート製剤 / BRONJ / デンタルインプラント / 病因 / 病態

Outline of Final Research Achievements

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first reported in 2003. Recently, it has been reported that BRONJ around dental implant occurred in patients taking bisphosphonates. However, the exact mechanism and pathology of BRONJ around dental implant are unknown. The aims of this study were 1) to develop BRONJ-like lesions around implant using Rats, and 2) to histologically investigate pathology of BRONJ-like lesions. Bisphosphonate/dexamethasone combination therapy, but not bisphosphonate monotherapy prevalently induced BRONJ-like lesions around implants with extended open wound, exposed necrotic bone and severe infiltration of polymorphonuclear cells in the connective tissue of tooth extraction sockets. Our findings may contribute to scientific evidences in related to BRONJ around dental implant.

Free Research Field

補綴系歯学関連